CMIC seminar: Imaging myelin and iron in the brain
This talk given by Jongho Lee from Seoul National University will summarise the methodological and reproducibility issues in network reconstruction from diffusion MRI data, with reference to the recent literature.
About
Mapping the whole-brain white matter connectivity profile using diffusion-weighted imaging has recently become a popular research topic in neuroscience. The brain is considered as network of grey matter regions linked by white matter tracts and so the structural network can be reconstructed by quantifying the connectivity between all brain regions using tractography techniques. Various network properties can then be derived using mathematical concepts from graph theory. Studies have shown that network properties such as global clustering coefficient and pathlength, which describe the segregation and integration properties of the network, are conserved among healthy individuals and altered in cases of disease, meaning such metrics may be potential disease biomarkers. However, a variety of methodologies may be employed to reconstruct the structural network and there is currently no consensus on which pipeline produces metrics of the highest anatomical relevance or are most sensitive to disease. This talk will summarise the methodological and reproducibility issues in network reconstruction from diffusion MRI data, with reference to the recent literature. Reproducibility of network metrics obtained by applying two different pipelines to diffusion MRI data acquired in triplicate from a group of healthy subjects will then be discussed.
Visitors from outside UCL please email in advance.
Jongho Lee
Associate Professor
Seoul National University
Jongho Lee is Associate Professor at the Department of Electrical and Computer Engineering, Seoul National University. He received his Ph.D in Electrical Engineering at Stanford University (2007). He worked at National Institutes of Health as a research fellow (2007 to 2010) and then at the Department of Radiology, University Pennsylvania as Assistant Professor (2010 to 2014). In 2014, he moved back to Korea to join a faculty position at Seoul National University. His lab is focused on the exploration of contrast mechanisms in MRI and development of novel neuroimaging methods.
