Research Projects
A list of current and past research projects, all of which are collaborations with industrial partners
2020/2021
| Project title | Researcher | Supervisor(s)/Industrial Partner |
|---|---|---|
3D measurement of fouling in membrane filtration: towards model based investigation and design | Piotr Kucia | Prof Daniel Bracewell & Dr Thomas Johnson PALL |
Design and characterisation of a scale down perfusion platform for mammalian cell process development | Ciara Lucas | Prof Martina Miceletti & Dr Andrea Rayat PALL |
Nanofibre adsorbent design informed by mechanistic modelling of bioprocess performance | Gyorgy Ovari | Prof Daniel Bracewell & Dr Stephen Goldrick Cytiva |
Scalable production of bioengineered fur products | Matt Wasmuth | Dr Darren Nesbeth & Dr Kenth Gustafsson Furoid |
2019/2012
| Project title | Researcher | Supervisor(s)/Industrial Partner |
|---|---|---|
| Big data analytics streamlining therapeutic drug development from micro-scale through to industrial-scale | Haneen Alosert | Professor Suzanne Farid and Dr Stephen Goldrick |
| Understanding the impact of shear stresses on different cell lines in the Allegro STR system | Jordan Delbridge | Professor Martina Micheletti and Dr Andrea Ducci |
| Evaluating the impacts of pumping stress on aggregate formation during Tangential Flow Filtration | Thomas Fanthom | Professor Daniel Bracewell and Professor Paul Dalby |
| Decisional tool to aid portfolio selection decisions into new modalities. | Annabel Lyle | Professor Suzanne Farid and Dr Stephen Goldrick |
| Development of a scalable and consistent process for the production of lentivirus for gene-modified cell therapies | Carme Ripoll Fiol | Dr Qasim Rafiq and Dr Andrea Rayat |
| Development and optimisation of novel bioprinting process for scalable production of tissue models using FRESH technique | Patricia Santos Beato | Dr Deepak Kalaskar and Dr Ryo Torri |
2018/2019
| Project title | Researcher | Supervisor(s)/Industrial Partner |
|---|---|---|
| Development of a microfluidic bioanalytical device for the characterization of cellular therapeutic products | Jorge Aranda-Hernandez | Professor Nicolas Szita and Dr Alex Kiparissides |
| Optimal Bioreactor: concept / design and implementation for CAR-T cell production | Alexander Davidson | Dr Qasim Rafiq and Professor Dan Bracewell |
| Ultra scale-down studies to investigate the impact of pre-column filtration on resin re-use and column fouling | Ifham Mirza | Dr Andrea Rayat and Dr Martina Micheletti |
| Sterilisable, biocompatible, immersible, spectroscopic planar imaging system | Rob Platten | Dr Qasim Rafiq and Professor Dan Bracewell |
| Continuous manufacture of lentivirus vectors for therapeutic vaccine applications | Dale Stibbs | Dr Andrea Rayat and Dr Qasim Rafiq |
| Optical deconvolution of multiple co-eluting proteins in chromatography | Deniz Ucan | Professor Paul Dalby and Dr Alex Kiparissides |
2017/2018
| Project title | Researcher | Supervisor(s)/Industrial Partner |
| A high throughput, multidimensional approach to engineering biology using automated workflows | Shama Chilakwad | Profs Gary Lye and John Ward Synthace |
| Process development for recovery and purification of exosomes for regenerative therapy | Benjamin Barnes | Prof Dan Bracewell ReNeuron |
| Development of an automated turbidostat platform for the investigation and characterization of the effects of environmental and process parameters on the physiology and metabolism of green algae | Matthew Booth | Drs Alex Kiparissides and Martina Micheletti Algenuity |
| Continuous Bioprocess Facilities of the Future: Integrated Drug Development & Manufacturing Economics Evaluation | Hanna Mahal | Prof Suzy Farid and Dr Ajoy Velayudhan CPI |
| Process interactions between filtration and chromatographic steps in mAb processing | Maria Parau | Profs Dan Bracewell and Mike Hoare Fujifilm |
| An ultra scale-down study of normal flow depth filtration for bioprocess recovery | Fathima Shazeena Rauf | Profs Mike Hoare and Dan Bracewell PALL |
2016/2017
| Project title | Researcher | Supervisors/Industrial Partner |
| Bioprocessing of human T-cells to advance cellular immunotherapies | Elena Costratio | Drs Ivan Wall and Martina Micheletti Sonics |
| 3D polymer scaffolds for the activation of CAR-T cell growth | Rebecca Gunn | Dr Farlan Veraitch and Prof. Dan Bracewell Spheritech |
| Design, synthesis and evaluation of agarose chromatography resins to meet the evolving needs of biologics manufacture | Greta Jasulaityte | Prof. Dan Bracewell and Dr Alex Kiparissides Purolite |
| An upstream process for removing contaminating cell types from primary T-cell preparations | Elsa Noaks | Dr Ivan Wall and Prof. Dan Bracewell Autolus |
| Rapid cell culture process development and optimisation using a new micro bioreactor system and advanced modelling approaches | Vincent Wiegmann | Drs Frank Baganz and Alex Kiparissides Applikon |
2015/2016
| Project title | Researcher | Supervisor(s) |
| Development of DNA nanopores for unitisation in different biochemical applications | Patrick Arnott | Dr Stefan Howorka and Prof. Gary Lye |
| Decisional tool for production planning across clinical development of biopharmaceutical portfolios | Max Baron | Profs Suzy Farid and Nigel Titchener-Hooker |
| Supply chain economics of clinical and commercial autologous ex vivo cell-gene therapy manufacture | Ruxandra Comisel | Prof Suzy Farid and Dr Tarit Mukhopadhyay |
| A Microfluidic approach to test for CQAs of lentiviral vectors for gene therapy vaccinations | Joe Harvey | Prof Nicolas Szita and Dr Tarit Mukhopadhyay |
| A combined multi-scale modelling and experimental investigation of the effects of Lactate metabolism on mammalian cell bioprocessing | Max Lularevic | Drs Alex Kiparissides and Cloe Kontoravdi (Imperial) |
| Efforts to establish Cocal-G enveloped lentiviral producers and Car19 transgene for the purpose of future bioprocessing and comparison to VSV-G Envelopes | Chris Perry | Drs Tarit Mukhopadhyay and Yasu Takeuchi |
| Integrating upstream and recovery scale-down mimics with predictive modelling for the evaluation of the process’s window of operation | Martina Sebastian | Profs Suzy Farid and Nigel Titchener-Hooker |
| Designer virus like particle (VLP) assembly in microbial expression system | Sarah Slack | Dr Tarit Mukhopadhyay and Prof. Dan Bracewell |
| Ultra scale-down mimics for perfusion culture: experimental and modelling optimisation study for rapid biopharmaceutical process development | Molly Tregidgo | Dr Martina Micheletti and Prof. Suzy Farid |
| Simulating the effect of large scale bioreactor heterogeneities on cell culture performance: a combined experimental and modelling approach | Roman Zakrzewski | Prof Gary Lye and Dr Alex Kiparissides |
2014/2015
| Project title | Researcher | Supervisor(s) |
| The use of continuous flow bioconversion reactors in novel biorefinery applications | Roberto Chiocchio | Profs. Gary Lye and |
| Process development for recovery and purification of exosomes for regenerative therapy | Ivano Colao | Dr Ivan Wall and Prof Dan Bracewell |
| Ultra scale-down (USD) methods for enhanced insight of membrane processing of engineered proteins | Lara Fernandez Cerezo | Profs Mike Hoare and Gary Lye |
| Development of an automated high-throughput purification methodology for macromolecular medicines | Vivien Fischer | Profs Aly Velayudhan and Eric Fraga |
| X-ray tomography for the characterisation of bioseparation materials | Thomas Johnson | Prof Dan Bracewell and Dr Paul shearing |
| A scale-down engineering study of key steps in the manufacture of a medicinal toxin | Darryl Kong | Profs Nigel Titchener-Hooker and Dan Bracewell |
| Nanoscale high-throughput whole-process analytics to monitor key quality attributes | Zaenab Oshinbolu | Profs Dan Bracewell and Paul Dalby |
2013/2014
| Project title | Researcher | Supervisor(s) |
| Gene Delivery Vector Platforms for Novel Gene Therapies | Ali Sadfer | Dr Darren Nesbeth, Prof Chris Mason |
| Real-Time Visualisation of Protein Self-Assembly | Hasan Alkaseem | Dr Bart Hoogenboom, Dr Daniel Bracewell |
| Novel Chassis for Engineered Pathways | Aisha Asra | Prof John Ward |
| Ruchika Bandekar | Prof Gary Lye | |
| Financial and Operational Perspectives of Cell Therapy Bioprocessing | Tania Chilma | Dr Suzanne Farid, Dr Sofia Simaria |
| Optimisation of Antibody Expression and Recovery from High Cell Density Microbial Fermentations at the Microwell Scale | Mary Lunson | Prof Gary Lye |
| Understand cell lysis in fermentation and primary recovery by online viscosity sensor | Joseph Newton | Dr Yuhong Zhou |
| Bioabsorbable tracheal scaffolds for clinical application | Toby Proctor | Prof Chris Mason, Dr Farlan Veraitch |
| S-Layer Lattice Assembly for Biotechnological Applications | Bouran Sohrabi | Dr Stefan Howorka, Prof Gary Lye |
| Leveraging High-Throughput Purification Data using Advanced Visualisation and Predictive Tools | Christos Stamatis | Dr. Suzanne Farid, Prof Nigel Titchener-Hooker |
| Nanofibre Adsorbents as a Purification Platform for Emerging Viral Vectores and Vaccines | Jordan Turnbull | Dr Daniel Bracewell |
2012/2013
| Title | Researcher | Supervisor(s) |
| An Integrated Scale-Down Platform for the Extraction and Recovery of Periplasmically Expressed Complex Molecules from E.Coli | Asma Ahmad | Dr Martina Micheletti, Prof Eli Keshavarz-Moore |
| Scalable Production of Tissue Engineered Microunits for Bone Regeneration Using Bioactive Glass Microshperes and Dynamic Culture Conditions | David De Silva Thompson | Dr Ivan Wall, Dr Martina Micheletti |
| Primary recovery of high-value products from high cell density harvests | Anne Marie De Villiers | Dr Tarit Mukhopadhyay, Prof Nigel Titchener-Hooker |
| Rapid Fermentation Process Optimisation using State-of-the-Art Mini Bioreactors and Advanced Modelling Approaches | Aaron Erbas | Dr Frank Baganz, Prof Gary Lye |
| Induced Pluripotent Stem Cell Processing for Drug Discovery Platforms and Cell therapy Products: Process Economics | Michael Jenkins | Dr Suzanne Farid, Dr Sofia Simaria |
| Evaluation of Biological and Process Options for Alkaline Biooxidations | Johannes Kolmar | Dr Frank Baganz |
| Development of Synthetic Shear Tracer Particles for Scale-Down Models of Continuous Centrifugation and Density Gradient Ultra-Centrifugation and a Mimic of Various Vaccine Candidates | Beatrice Melinek | Dr Tarit Mukhopadhyay, Dr Daniel Bracewell |
| Understanding Protease Contaminants during Biopharmaceutical Manufacture from CHO Cell Culture | Damiano Migani | Dr Daniel Bracewell, Prof Mark Smales |
| A Comparison between Aqueous Two-Phase Extraction and Chromatography for the Separation of Novel Biopharmaceuticals using High Throughput Process Development (HTPD) Methodologies | Nehal Patel | Dr Daniel Bracewell, Dr Eva Sorensen |
| Rapid Materialisation of Synthetic Biology Products | James Rutley | Prof Gary Lye, Dr Martina Micheletti |
| Purification of Recombinnat Vaccinia Viruses for Cancer Therapy and Cancer Vaccine using Monolthic Column Technology | David Vincent | Dr Yuhong Zhou, Dr Daniel Bracewell |
2011/2012
| Title | Researcher | Supervisor(s) |
| Novel Strategies for Early Downstream Processing of High-Density Mammalian Cell Culture | Georgina Espuny Garcia Del Real | Dr Daniel Bracewell, Prof Michael Hoare |
| Scale-Down Characterisation and Modelling of Harvest Operations in Cell Culture Processes | Joseph Allen | Prof Nigel Titchener-Hooker, Dr Suzanne Farid |
| Developing a Novel and Cost-Effective Method of Purification or Therapeutic Proteins using Affinity Tags | Adam McInally | Prof Michael Hoare, Dr Paul Dalby |
| Engineering Characterisation of Cylindrical Shaken Bioreactors for Improved Cell Culture Process Development and Scale-Up | Gregorio Rodriguez | Dr Martina Micheletti, Dr Andrew Ducci (UCL Chemical Engineering) |
| Cell and Protein Engineering Strategies to Maximise the Recovery and Dimerisation of a Biotherapeutic Antibody-Enzyme Fusion Protein Produced in E.Coli | Desmond Schofield | Dr Darren Nesbeth, Dr Kerry Chester (UCL Oncology) |
| Applications of an Ultra-Rapid Next-Gen Thermocycler in PCR-based Bioprocess Monitoring | Alex Templar | Dr Darren Nesbeth, Prof Eli Keshavarz-Moore |
| An Upstream Platform for the Production of High Grade Heterologous Proteins in Pichia Pastoris | Ben Weil | Dr Darren Nesbeth, Dr Daniel Bracewell |
2010/2011
| Title | Researcher | Supervisor(s) |
| Scale Down and Optimisation of a Novel Second Generation Bioethanol Process | Neil Conroy | Prof Gary Lye, Dr Paul Dalby |
| Microscale Methods for the Rapid Analysis of Antibiotic Compound Libraries and Systematic Downstream Process Design | Haroon Khan | Prof Gary Lye, Dr Nicholas Szita |
| An Ultra Scale-Down Tool for the Predicitve Design of a Filtration Procedure for Preparation of Human Cell Therapies | Chris Longster | Prof Michael Hoare, Dr Ivan Wall |
| Engineering Characterisation of Single-Use Wave-Type Bioreactors for Improved Cell Culture Process Development and Scale-Up | Douglas Marsh | Prof Gary Lye, Dr Martina Micheletti |
| Design and Evaluation of an Internally Radiating Photobioreactor for Generic Application in the Algal Production of Biofuels, Biorenewable Chemicals and Biopharmaceuticals | Kane Miller | Prof Gary Lye, Dr Martina Micheletti |
| High Throughput Protein Precipitation for Monoclonal Antibody Purification | Chris Morris | Prof Nigel Titchener-Hooker, Dr Paul Dalby |
| Streamlined Purification and Process Understanding of Polysaccharide Vaccine Components | Aaron Noyes | Dr Tarit Mukhopadhyay, Prof Nigel Titchener-Hooker |
| Towards a More Efficient Platform for Inclusion Body Processing from Engineered E.Coli | Aminat Omotosho | Prof Eli Keshavarz-Moore, Dr Gareth Mannall |
| Novel Primary Recovery Srategies for High Cell Density Mammalian Cell | Daria Popova | Prof Nigel Titchener-Hooker, Dr Suzanne Farid |
| Non-Geometric Scale Up of Chromatographic Separations of Biopharmaceuticals | Jayan Senaratne | Prof Nigel Titchener-Hooker, Dr Daniel Bracewell |
| Controlling Early Cell Human Embryonic Stem Cell Fate with Growth Factors and Oxygen Concentration | Vishal Sharma | Dr Farlan Veraitch, Dr Nicholas Szita |
| Production Planning across Multi-Site, Multi-Product Biopharmaceutical Plants under Uncertainty | Cyrus Siganporia | Dr Suzanne Farid, Dr Lazaros Papageorgiou |
2009/2010
| Title | Researcher | Supervisor(s) |
| Improving Bone Marrow Stem Cell Therapy for Cardiac Repair | Owen Bain | Dr Ivan Wall, Prof Chris Mason |
| Incorporation of Developability into Cell Line Selection: Creation of a Simplified High-Throughput Small-Scale Model for a mAb Manufacturing Process | John Betts | Prof Gary Lye, Dr Frank Baganz |
| Small Scale, High Throughput Process Development with a Focus on Novel Therapeutic Proteins | Alex Chatel | Prof Mike Hoare, Prof Nigel Titchener-Hooker |
| Process Modelling Approaches to Biological Complexity in the Production of Therapeutic Proteins | Edward Close | Dr Daniel Bracewell, Dr Eva Sorensen |
| Microscale Characterisaton of a Manufacturing Route for Lentiviral Vectors | Heather Guy | Dr Tarit Mukhopadhyay, Prof Gary Lye |
| Measurement of Protein Self-Association Behaviour as a Determinant of Aggregation in Bioprocessing | Krisztina Kovacs-Schreiner | Dr Daniel Bracewell, Prof Michael Hoare |
| A Microscale Purification Platform for the Study of Fusion Protein Recovery | Eduardo Lau | Prof Michael Hoare, Dr Paul Dalby |
| Dental Stem Cells for Tooth Regeneration and Repair | Yvonne Pang | Dr Ivan Wall, Prof Chris Mason |
| Scale-Up of Tissue Engineering Trachea using Adult Stem Cells | Leanne Partington | Dr Ivan Wall, Prof Chris Mason |
| The Bioprocessing of Human Embryonic Stem Cells to Treat Blindness | Iwan Thomas Roberts | Prof Chris Mason, Prof Peter Coffey |
| Investigation of IgG Aggregate Formation in Biopharmaceutical Processes; A Study of the Location and Mechanism of Aggregation | Roumteen Tavakoli-Keshe | Dr Daniel Bracewell, Prof Nigel Titchener-Hooker |
| Scaling Omnicyte (Adult Stem Cells) Therapy for Safe, Effective and Affordable Clinical Use. Characterisation of miRNAs for Stem Cell Expansion and Regenerative Medicine | John Thwaites | Dr Ivan Wall, Prof Chris Mason |
| Pre-Formulation Screening: High Throughput Tools to Formulate dABs and Predict Stability Profiles | Udofoyo Uye | Dr Paul Dalby, Prof Michael Hoare |
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