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Biography
Professor Chilvers graduated from Nottingham and following junior posts at the Hammersmith, St Thomas' and Royal Brompton Hospitals undertook an MRC Training Fellowship with Professor Steve Nahorski at Leicester where he studied the role of phosphoinositide signaling in airways smooth muscle. He then took up a Lectureship at Edinburgh, working with Professor Chris Haslett, and subsequent Wellcome Trust Senior Clinical Fellowship where he focused on the role of PI3-kinase signaling in neutrophil priming and apoptosis. He started his current post in 1998, and heads the Respiratory Medicine Division, with >80 research staff plus a large clinical team. His other roles include Director of the Clinical Academic Training Office (CATO), Deputy Head of the Department of Medicine and Chair of the UK Association of Clinical Professors in Medicine. He was elected a Fellow of the Academy of Medical Sciences in 2007.
Research Interests
My group is interested in the intracellular mechanisms regulating NADPH oxidase function in neutrophils and the control of neutrophil and eosinophil survival by hypoxia and inflammatory cytokines. This work has a particular focus on the role of phosphoinositide 3-kinase and HIF-alpha isoforms in these processes. We also have a translational research programme, which uses radiolabelled autologous granulocytes (both neutrophils and eosinophils) combined with SPECT-CT to examine granulocyte kinetics, function and fate in vivo.
Key publications
Thomas DC, Clare S, Sowerby JM, Pardo
M, Juss JK, Goulding DA, Van der Weyden L, Storisteanu DML, Prakash A, Espeli
M, Flint S, Lee JC, Kane L, Hoenderdos K, Adams D, Bateman A, Chaudhry J, Lyons
PA, Condliffe AM, Chilvers ER, Dougan G, Smith KGC. Eros, a
novel trans-membrane protein, controls the reactive oxygen burst and is
essential for innate immunity. J Exp Med 2017; in press.
Thompson AAR, Dickinson RS, Marriott HM, Williams L, Murphy F, Lewis A, Hameed A, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Simon MC, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Whyte MKB, Walmsley SR. Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism. Science Immunol 2016; in press.
Cader MZ, Kempster SL, Boroviak K, Zhang Q, Assadi G, Sewell G, Clare S, Saveljeva S, Mukhopadhyay S, Brown KP, Ashcroft JW, Tschurtschenthaler M, Raine T, Chilvers ER, Kaneider NC, Floto RA, d'Amato M, Wakelam MJ, Bradley A, Dougan G, Kaser A. C13orf31 (FAMIN) is a central regulator of immunometabolic function. Nat Immunol 2016; 17: 1046-56.
Angulo-Herrera I, Vadas O, Garson F, Banham-Hall E, Plagnol V, Leahy R, Baxendale H, Coulter T, Curtis J, Wu C, Perisic O, Smith D, Fiddler C, Juss J, Cilliers D, Markelj G, Farmer G, Stephens L, Hawkins P, Abinun M, Clatworthy M, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe AM, Nejentsev S. Phosphoinositide 3-kinase delta activity mutation predisposes to infection and airway damage. Science 2013; 342:866-71.
Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling J, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS# (#joint corresponding authors). Differential regulation of systemic arterial pressure by the skin: role of HIF isoforms. PNAS 2013; 110:17570-5.
