This dataset is made available through the support of the UK Alzheimer's Society. The original data collection was funded through an unrestricted educational grant from GlaxoSmithKline and funding from the UK Alzheimer's Society (to Dr Schott) and the Medical Research Council (to Professor Fox). Professor Ourselin receives funding from the EPSRC (EP/H046410/1) and the Comprehensive Biomedical Research Centre (CBRC) Strategic Investment Award (Ref. 168). Dr Ridgway is supported by the Medical Research Council [grant number MR/J014257/1]. This work was supported by the National Institute for Health Research (NIHR) Biomedical Research Unit in Dementia based at University College London Hospitals (UCLH), University College London (UCL). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The Dementia Research Centre is an Alzheimer's Research UK (ARUK) Coordinating Centre. The Wellcome Trust Centre for Neuroimaging is supported by core funding from the Wellcome Trust [grant number 091593/Z/10/Z]. We are grateful to the MIRIAD participants and funders for their willingness to share these data.