The Comprehensive Clinical Trials Unit at UCL



1 November 2018

A Randomised, Single Masked, Non-Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract

Funded by the National Institute of Health Research Health Technology Assessment, FACT is a multi-centre randomised, single masked, non-inferiority trial to compare Femtosecond Laser Assisted and Manual Phacoemulsification Cataract Surgery in adults with visually significant cataract.

Computer controlled laser platforms can automate over half the steps currently completed by hand in cataract surgery. The theoretical advantages of laser assisted cataract surgery include greater safety, better vision and potentially lower long-term health costs through greater efficiency and safety.

The trial will inform NHS service providers, commissioners, patients and ophthalmologists about the effectiveness and cost-effectiveness of these two ways of performing cataract surgery and will help to guide the possible introduction of laser assisted cataract surgery in the NHS.

FACT is now closed.