The Comprehensive Clinical Trials Unit at UCL



1 November 2018

MS-STAT2 : Multiple Sclerosis - Simvastatin Trial 2
The MS-STAT2 clinical trial has been designed to test the effectiveness of repurposed simvastatin (80mg) in patients with secondary progressive MS (SPMS), to determine if the rate of disability progression can be slowed over a 3 year period.

SPMS results from a progressive neuronal degeneration that causes accumulated and irreversible disability affecting walking, balance, manual function, vision, cognition, pain control, bladder and bowel function. The pathological process driving the development of this disability is not known at present.

While treatments in the early stage of MS (relapsing-remitting MS, or RRMS) have become increasingly effective, there remains no current disease-modifying treatment (DMT) for SPMS. An earlier study, MS-STAT1, used magnetic resonance imaging (MRI) techniques to determine that patients taking simvastatin over a two year period resulted in a reduced rate of brain atrophy (a loss of neurons, or ‘brain shrinkage’) compared to those taking a placebo.  That study took place with 140 patients, whereas the MS-STAT2 trial will increase patient participation considerably in an effort to determine whether simvastatin can become a DMT for SPMS.
Trial status: Ongoing. Recruitment open.
Funder: National Institute for Health Research
Sponsor: University College London