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The Comprehensive Clinical Trials Unit at UCL

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OPTIMAS

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5 April 2018


Chief Investigator: Professor David Werring (UCL)

OPTIMAS is a multicentre randomised controlled trial of early vs standard, guideline-based timing of anticoagulation  with a DOAC in patients with atrial fibrillation and acute ischaemic stroke.

Eligibility: Adult patients with nvAF and clinical diagnosis of acute ischaemic stroke, eligible for DOAC treatment. 

Intervention: Anticoagulation with any DOAC within 4 days of acute ischaemic stroke

Control: Anticoagulation with any DOAC at 7—14 days of acute ischaemic stroke

Key Outcomes: combined incidence of symptomatic ICH, ischaemic stroke and systemic embolism at 90 days; intracranial and major extracranial bleeding

Imaging: encouraged but no specific requirements for study entry

Anticipated First Recruitment: February 2019

Target Sites:  >100 in UK (70 EoI to date)

Interested? Email ctu.optimas@ucl.ac.uk

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