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The Comprehensive Clinical Trials Unit at UCL

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Trials A-Z

A full list of all our current and completed trials here at the Comprehensive Clinical Trials Unit.

All

ADEPT-PD

Antidepressants in Parkinson's Disease.

ASEPTIC

Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis.

ATTIRE

Albumin To prevenT Infection in chronic liveR failurE.

BEAT Lupus

Safety and Efficacy of Belimumab after B cell Depletion Therapy in Systemic Lupus Erythematosus.

COG-UK HOCI

A phase III prospective, interventional, cohort, superiority study to evaluate the benefit of rapid COVID-19 genomic sequencing (the COVID-19 GENOMICS UK project) on infection control in preventing the spread of the virus in United Kingdom NHS settings.

COMPARE 

Combination therapy for Pulmonary hypertension using RacEcadotril

CROWN CORONATION

International, Bayesian platform adaptive, randomized, placebo-controlled trial assessing the effectiveness of candidate interventions in preventing COVID-19 disease in adults.

DARC II

Retinal biomarkers of Alzheimer's disease in Down's syndrome.

DESPIAD

Depletion of serum Amyloid P Component in Alzheimer's Disease.

EVERREST

Developing a therapy for Fetal Growth Restriction.

EXENATIDE-PD3

A randomised, double blind, parallel group, placebo controlled Phase 3 trial of Exenatide once weekly over 2 years as a potential disease modifying treatment for Parkinson's disease.

FACT

A Randomised, Single Masked, Non-Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract.

FLARE

Favipiravir +/- Lopinavir: A RCT of Early antivirals

HIPVAC

Human papillomavirus infection.

HORACE

Phase I/II open label, multicentre clinical trial to assess the safety and efficacy of ssAAV-LK03.hAAT.hcoOTC (Gene Therapy) for paediatric patients with ornithine transcarbamylase deficiency.

KERALINK

A Phase II Clinical Trial to establish Efficacy and Safety of cross-linking in children with Keratoconus.

METRIC

Magnetic resonance Enterography (MRE) or ulTRasound In Crohn’s disease Extended Follow-up for predicting disabling disease.

MIA

Minimally invasive autopsy for fetuses and children based on a combination of post-mortem MRI and endoscopic examination: a feasibility study.

MICE

Integrating Care for young people with epilepsy.

MINIMISE

Mycophenolate in limited cutaneous systemic sclerosis

MOTILITY

MRI for early response prediction to anti-TNF therapy.

MS-STAT2

MS-STAT2 : Multiple Sclerosis - Simvastatin Trial 2.

OPTIMAS

OPtimal TIMing of Anticoagulation after Stroke

RAFT

First in Human Phase I/II Clinical Trial of RAFT for Aniridia Related Keratopathy.

RAPS

A prospective randomised controlled phase II/III non-inferiority clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE

RESPONSE

Phase 1 safety study of Recombinant Surfactant Protein D to prevent neonatal Chronic Lung Disease (nCLD) in preterm infants.

RISAPS

A prospective randomised controlled phase II clinical trial of rivaroxaban versus warfarin in stroke patients with antiphospholipid syndrome, with or without SLE.

SPREE

Screening programme for pre-eclampsia.

TARVA

Total Ankle Replacement vs Arthrodesis.

A

ADEPT-PD

Antidepressants in Parkinson's Disease.

ASEPTIC

Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis.

ATTIRE

Albumin To prevenT Infection in chronic liveR failurE.

B

BEAT Lupus

Safety and Efficacy of Belimumab after B cell Depletion Therapy in Systemic Lupus Erythematosus.

C

COG-UK HOCI

A phase III prospective, interventional, cohort, superiority study to evaluate the benefit of rapid COVID-19 genomic sequencing (the COVID-19 GENOMICS UK project) on infection control in preventing the spread of the virus in United Kingdom NHS settings.

COMPARE 

Combination therapy for Pulmonary hypertension using RacEcadotril

CROWN CORONATION

Chloroquine RepurpOsing to healthWorkers for Novel CORONAvirus mitigaTION.

D

DARC II

Retinal biomarkers of Alzheimer's disease in Down's syndrome.

DESPIAD

Depletion of serum Amyloid P Component in Alzheimer's Disease.

E

EVERREST

Developing a therapy for Fetal Growth Restriction.

EXENATIDE-PD3

A randomised, double blind, parallel group, placebo controlled Phase 3 trial of Exenatide once weekly over 2 years as a potential disease modifying treatment for Parkinson's disease.

F

FACT

A Randomised, Single Masked, Non-Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract.

FLARE

Favipiravir +/- Lopinavir: A RCT of Early antivirals

G

 

H

HIPVAC

Human papillomavirus infection.

HORACE

Phase I/II open label, multicentre clinical trial to assess the safety and efficacy of ssAAV-LK03.hAAT.hcoOTC (Gene Therapy) for paediatric patients with ornithine transcarbamylase deficiency.

I

 

J

 

K

KERALINK

A Phase II Clinical Trial to establish Efficacy and Safety of cross-linking in children with Keratoconus.

L

 

M

METRIC

Magnetic resonance Enterography (MRE) or ulTRasound In Crohn’s disease Extended Follow-up for predicting disabling disease.

MIA

Minimally invasive autopsy for fetuses and children based on a combination of post-mortem MRI and endoscopic examination: a feasibility study.

MICE

Integrating Care for young people with epilepsy.

MINIMISE

Mycophenolate in limited cutaneous systemic sclerosis

MOTILITY

MRI for early response prediction to anti-TNF therapy.

MS-STAT2

MS-STAT2 : Multiple Sclerosis - Simvastatin Trial 2.

N

 

O

OPTIMAS

OPtimal TIMing of Anticoagulation after Stroke

P

 

Q

 

R

RAFT

First in Human Phase I/II Clinical Trial of RAFT for Aniridia Related Keratopathy.

RAPS

A prospective randomised controlled phase II/III non-inferiority clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE

RESPONSE

Phase 1 safety study of Recombinant Surfactant Protein D to prevent neonatal Chronic Lung Disease (nCLD) in preterm infants.

RISAPS

A prospective randomised controlled phase II clinical trial of rivaroxaban versus warfarin in stroke patients with antiphospholipid syndrome, with or without SLE.

S

SPREE

Screening programme for pre-eclampsia.

T

TARVA

Total Ankle Replacement vs Arthrodesis.

U

 

V

 

W

 

X

 

Y

 

Z