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The Comprehensive Clinical Trials Unit at UCL

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Trials A-Z

A full list of all our current and completed trials here at the Comprehensive Clinical Trials Unit.

All

ADEPT-PD

Antidepressants in Parkinson's Disease.

ASEPTIC

Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis.

ATTIRE

Albumin To prevenT Infection in chronic liveR failurE.

BEAT Lupus

Safety and Efficacy of Belimumab after B cell Depletion Therapy in Systemic Lupus Erythematosus.

COG-UK HOCI

A phase III prospective, interventional, cohort, superiority study to evaluate the benefit of rapid COVID-19 genomic sequencing (the COVID-19 GENOMICS UK project) on infection control in preventing the spread of the virus in United Kingdom NHS settings.

CROWN CORONATION

International, Bayesian platform adaptive, randomized, placebo-controlled trial assessing the effectiveness of candidate interventions in preventing COVID-19 disease in adults.

DARC II

Retinal biomarkers of Alzheimer's disease in Down's syndrome.

DESPIAD

Depletion of serum Amyloid P Component in Alzheimer's Disease.

EVERREST

Developing a therapy for Fetal Growth Restriction.

EXENATIDE-PD3

A randomised, double blind, parallel group, placebo controlled Phase 3 trial of Exenatide once weekly over 2 years as a potential disease modifying treatment for Parkinson's disease.

FACT

A Randomised, Single Masked, Non-Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract.

FLARE

Favipiravir +/- Lopinavir: A RCT of Early antivirals

HIPVAC

Human papillomavirus infection.

HORACE

Phase I/II open label, multicentre clinical trial to assess the safety and efficacy of ssAAV-LK03.hAAT.hcoOTC (Gene Therapy) for paediatric patients with ornithine transcarbamylase deficiency.

KERALINK

A Phase II Clinical Trial to establish Efficacy and Safety of cross-linking in children with Keratoconus.

METRIC

Magnetic resonance Enterography (MRE) or ulTRasound In Crohn’s disease Extended Follow-up for predicting disabling disease.

MICE

Integrating Care for young people with epilepsy.

MINIMISE

Mycophenolate in limited cutaneous systemic sclerosis

MOTILITY

MRI for early response prediction to anti-TNF therapy.

MS-STAT2

MS-STAT2 : Multiple Sclerosis - Simvastatin Trial 2.

OPTIMAS

OPtimal TIMing of Anticoagulation after Stroke

RAFT

First in Human Phase I/II Clinical Trial of RAFT for Aniridia Related Keratopathy.

RESPONSE

Phase 1 safety study of Recombinant Surfactant Protein D to prevent neonatal Chronic Lung Disease (nCLD) in preterm infants.

RISAPS

A prospective randomised controlled phase II clinical trial of rivaroxaban versus warfarin in stroke patients with antiphospholipid syndrome, with or without SLE.

SPREE

Screening programme for pre-eclampsia.

TARVA

Total Ankle Replacement vs Arthrodesis.

A

ADEPT-PD

Antidepressants in Parkinson's Disease.

ASEPTIC

Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis.

ATTIRE

Albumin To prevenT Infection in chronic liveR failurE.

B

BEAT Lupus

Safety and Efficacy of Belimumab after B cell Depletion Therapy in Systemic Lupus Erythematosus.

C

COG-UK HOCI

A phase III prospective, interventional, cohort, superiority study to evaluate the benefit of rapid COVID-19 genomic sequencing (the COVID-19 GENOMICS UK project) on infection control in preventing the spread of the virus in United Kingdom NHS settings.

CROWN CORONATION

Chloroquine RepurpOsing to healthWorkers for Novel CORONAvirus mitigaTION.

D

DARC II

Retinal biomarkers of Alzheimer's disease in Down's syndrome.

DESPIAD

Depletion of serum Amyloid P Component in Alzheimer's Disease.

E

EVERREST

Developing a therapy for Fetal Growth Restriction.

EXENATIDE-PD3

A randomised, double blind, parallel group, placebo controlled Phase 3 trial of Exenatide once weekly over 2 years as a potential disease modifying treatment for Parkinson's disease.

F

FACT

A Randomised, Single Masked, Non-Inferiority Trial of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract.

FLARE

Favipiravir +/- Lopinavir: A RCT of Early antivirals

G

 

H

HIPVAC

Human papillomavirus infection.

HORACE

Phase I/II open label, multicentre clinical trial to assess the safety and efficacy of ssAAV-LK03.hAAT.hcoOTC (Gene Therapy) for paediatric patients with ornithine transcarbamylase deficiency.

I

 

J

 

K

KERALINK

A Phase II Clinical Trial to establish Efficacy and Safety of cross-linking in children with Keratoconus.

L

 

M

METRIC

Magnetic resonance Enterography (MRE) or ulTRasound In Crohn’s disease Extended Follow-up for predicting disabling disease.

MICE

Integrating Care for young people with epilepsy.

MINIMISE

Mycophenolate in limited cutaneous systemic sclerosis

MOTILITY

MRI for early response prediction to anti-TNF therapy.

MS-STAT2

MS-STAT2 : Multiple Sclerosis - Simvastatin Trial 2.

N

 

O

OPTIMAS

OPtimal TIMing of Anticoagulation after Stroke

P

 

Q

 

R

RAFT

First in Human Phase I/II Clinical Trial of RAFT for Aniridia Related Keratopathy.

RESPONSE

Phase 1 safety study of Recombinant Surfactant Protein D to prevent neonatal Chronic Lung Disease (nCLD) in preterm infants.

RISAPS

A prospective randomised controlled phase II clinical trial of rivaroxaban versus warfarin in stroke patients with antiphospholipid syndrome, with or without SLE.

S

SPREE

Screening programme for pre-eclampsia.

T

TARVA

Total Ankle Replacement vs Arthrodesis.

U

 

V

 

W

 

X

 

Y

 

Z