Polypharmacology Studied Using Structural Bioinformatics and Systems Biology


Dr. Phil Bourne, Skaggs School of Pharmacy and Pharmaceutical Sciences,
University of California San Diego, USA

Wednesday 8th December, Location: Gustave Tuck Lecture Theatre, Time: 15:00


Ehrlich's traditional view of one drug binding to one receptor to treat one disease is being replaced by a more systems based view where a drug is binding to multiple receptors with varying affinities and perturbing the whole system. If we could predict that perturbation in silico from single and multiple drug regimes we might be able to improve drugs and drug treatment strategies. We are a long way from this, but some progress is being made. I will describe our strategy for deciphering off-target binding of existing drugs and for measuring the impact on the complete system. I will illustrate our progress by describing work in constructing  the complete TB-drugome and for exploring the unanticipated anti-cancer effects of the HIV-1 protease inhibitor Nelfinavir. 

Further information including a list of relevant publications is available from http://www.sdsc.edu/pb


If you wish to meet with the speaker please contact Prof Christine Orengo (orengo@biochem.ucl.ac.uk) by 5pm, Tuesday 7th December

bourneposter




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