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Queen Square Centre for Neuromuscular Diseases

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Prof Dimitri Michael Kullmann

Prof Dimitri Michael Kullmann

Contacts

Address

828
Queen Square House
Queen Square
London
WC1N 3BG

Appointments

  • Professor of Neurology
    Clinical & Experimental Epilepsy
    UCL Queen Square Institute of Neurology

Joined UCL

1995-08-01

My interests span the fundamental mechanisms of synaptic transmission, the computational properties of small neuronal circuits, and alterations in neuronal and circuit excitability in epilepsy and other neurological disorders. The core methods in my lab are in vitro electrophysiology and pharmacology, but we also apply confocal and two-photon laser scanning microscopy, computational simulations, molecular genetic methods, and heterologous expression of mutated ion channels.

I collaborate with Michael Hanna, Henry Houlden, Stephanie Schorge and others to understand the mechanisms of inherited neurological diseases caused by mutations of ion channels (channelopathies).

My laboratory has contributed to the discovery of silent synapses, glutamate spillover, presynaptic GABAA receptors in the cortex, human epilepsy caused by K+ and Ca2+ channel mutations, tonic inhibition in the hippocampus, and Hebbian and anti-Hebbian LTP in hippocampal interneurons.

One of our goals is to understand how phenomena that we have studied at the cellular level (synaptic, extra-synaptic and non-synaptic signalling, different types of long-term potentiation) interact to regulate the excitability of small neuronal circuits. We are also integrating our studies on hippocampal circuit function with knowledge of how interneurons and principal cells fire during different behaviours. This is being approached with a synthesis of experiments and computational simulations. 


In collaboration with Matthew Walker, Stephanie Schorge, Rob Wykes and Dennis Kaetzel, my laboratory has developed several promising strategies for gene therapy of focal epilepsy.

Award year Qualification Institution
2000 FRCP
Fellow of the Royal College of Physicians
Medicine
Royal College of Physicians
1990 MRCP
Member of the Royal College of Physicians
Medicine
Royal College of Physicians
1986 MBBS
Bachelor of Medicine/Bachelor of Surgery
Medicine
University of London
1984 DPhil
Doctor of Philosophy
Physiological Science
University of Oxford
1979 BA Hons
Bachelor of Arts (Honours)
Physiological Science
Balliol College, Oxford

I studied Physiological Sciences (undergraduate Medicine) at Oxford University and obtained a DPhil in the laboratory of Julian Jack before resuming my clinical studies at St Thomas' Hospital (London). I then alternated between research in synaptic trasnsmission  (including a couple of years with Roger Nicoll, UCSF) and postgraduate medical training in London until I established my own laboratory at the Institute of Neurology in 1992.