AddressPaul O'Gorman Building
72 Huntley Street
Professor in Inherited Cardiovascular Disease
Institute of Cardiovascular Science
Professor Elliott's research focuses on advances in genomic medicine and their application to the diagnosis and management of inherited cardiovascular disease; in particular, he has developed low cost high throughput gene sequencing technologies (HTS) that interrogate the entire human genome and offer enormous opportunities for the advancement of knowledge about human health and disease. These are paired with systems that integrate large-scale phenotyping, bioinformatics and functional analyses.
High throughput genetic screening as a tool for early diagnosis
In our NIHR-BRC funded programme we have used hypertrophic cardiomyopathy (HCM) as a model for translation. HCM is a genetic disorder (1:500 adults) that causes sudden cardiac death , stroke and heart failure. It is characterised by marked variability in disease expression and despite 20 years of research, an understanding of genotype-phenotype relations in HCM had remained elusive. Professor Elliott's work shows that genetic heterogeneity causes different but predictable effects on cardiac phenotype and that creation of an integrated genetic testing pipeline can be used to guide therapy and counselling strategies in patients with this and other inherited cardiac diseases. These results are used in national and international guidance on genetic testing in families affected by inherited heart muscle disease:
Use of genotyping in prevention of sudden death
Dilated cardiomyopathy (DCM) affects 1 in 2500 people. Professor Elliott's work in patients with DCM caused by Lamin AC gene mutations (5-8% of call patients) shows that most people who inherit the gene develop disease with a predictable natural history beginning with atrial arrhythmia in early adulthood with subsequent progression to heart block, potentially fatal ventricular arrhythmia and finally progressive heart failure. Early recognition of these characteristic stages of disease facilitates much earlier diagnosis for patients and families and has led to development of predictive models that identify patients that benefit from early treatment with ICDs.
Clinical Risk Tools
Professor Elliott's risk algorithms for hypertrophic cardiomyopathy have formed the basis of International guidance on implantable cardioverter defibrillators (ICD) in European and American practice guidelines for over 10 years and are incorporated into specialist society statements
Prof. Perry M. Elliott is Research Lead of the Inherited Cardiovascular Disease Unit at the Bart’s Heart Centre, London, UK, and Professor of Cardiovascular Medicine at University College London (UCL). He studied medicine at St. Thomas’s Hospital Medical School, London. After qualifying in 1987 he trained in general medicine, gaining membership of the Royal College of Physicians in 1991, and completed his general cardiology training at St. George’s Hospital Medical School, London. He was appointed as Senior Lecturer first at St. George’s Hospital in 1999 and then at UCL in 2003. He was promoted to Reader in Inherited Cardiac Disease in 2005 and became a full Professor at UCL in 2012. He is cardiovascular lead for the North Thames NHS Genomic Medicine Centre, and a member of the Cardiovascular GeCIP [Cardiomyopathy subgroup] and Genomics England Pilot Steering Committee
Over the past 20 years, Prof. Elliott has established an international reputation in the field of heart muscle disease, authoring more than 300 peer-reviewed papers on the subject. He was elected as a Fellow of the European Society of Cardiology (ESC) in 2005, is past Chairman of the ESC Working Group on Myocardial and Pericardial Diseases (2010–2012), and chairs the ESC Guideline Task Force on Hypertrophic Cardiomyopathy and the Executive Committee for the European Outcomes Research Programme registry on cardiomyopathies. He has edited two books: Principles and Practice of Clinical Cardiovascular Genetics (Kumar & Elliott) ISBN13: 9780195368956. Mar 2010, Oxford University Press & Inherited Cardiac Disease (Oxford Specialist Handbooks in Cardiology) Elliott, Lambiase, Kumar. Oxford University Press. ISBN-13: 978-0199559688. July 2011. (Shortlisted BMJ Medical Books Award, 2012)
From 2009 to 2013, he was Deputy Editor of The Heart Journal and is currently Deputy Editor for the International Journal of Cardiology and an associate editor for the Journal of American College of Cardiology. He is President of the Cardiomyopathy Association.