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UCL-Francis Crick Institute PhD Studentship

A 3-year PhD Studentship funded by University College London (UCL) is available in the Mosaicism and Precision Medicine Laboratory at the internationally-renowned Francis Crick Institute in London.  The student will be enrolled with University College London (UCL) for the purposes of the degree.

The studentship will commence in October 2021 under the supervision of Professor Veronica Kinsler, Senior Group Leader, Francis Crick Institute, London; Professor of Paediatric Dermatology and Dermatogenetics, Great Ormond St Hospital and GOS UCL Institute of Child Health, London.

https://www.crick.ac.uk/research/labs/veronica-kinsler

and

Professor Wenyi Wang, Professor, Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

https://odin.mdacc.tmc.edu/~wwang7/index.html

Project description

The discovery of somatic mutational signatures is one of the great breakthroughs in the understanding of genetics in recent years.  Until now, somatic mutational profiling has largely been used to study cancers and normal human development.  This project will investigate the role of somatic mutational profile in de novo autosomal dominant genetic diseases, both germline and mosaic.  This highly innovative application of bioinformatics to the fundamentals of disease development is likely to lead to publication for a committed candidate. There is the possibility of combining the bioinformatics project with some wet lab work if the student wishes to develop skills in that direction.

For further details, please see the project description on the ICH Website: "Using somatic mutational profiling to model incidence and phenotypic variation in genetic disease"

The student will receive a starting stipend of £17,978 per annum (including London weighting) as well as the cost of tuition fees based on UK (Home) fee status. 

Personal Specification

Applicants should have, or expect to receive an upper second-class Bachelor’s degree and/or a Master’s degree (or equivalent work experience) in a relevant discipline or an overseas qualification of an equivalent standard.  This post is suitable for a variety of backgrounds. Previous training in statistics and/or computer science is a plus.

Eligibilty

This studentship covers the cost of tuition fees based on the UK (Home) rate.  Non-UK students can apply but will have to personally fund the difference between the UK (Home) rate and the overseas rate where they are not eligible for UK fee status.

NB: You will be asked about your likely fee status at the interview so we would advise you to contact the UCL Graduate Admissions Office for advice should you be unsure whether or not you meet the eligibility criteria for Home fee status.  Further information on Brexit and the definitions for fee status assessment can be found on the UCL website and also the UKCISA website (Higher Education: Definitions for fee status assessment).

Application

To apply, please send a current CV including the contact details of two professional referees as well as a cover letter to jane.white@crick.ac.uk. Enquiries regarding the post can be made to jane.white@crick.ac.uk.  Enquiries regarding the project can be made to veronica.kinsler@crick.ac.uk.

Deadline for receipt of applications: midnight 18th July 2021

Interview date: 28th July 2021