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Research Projects available from Autumn 2020:
- Developmental Biology and Cancer
Projects
Supervisors
Full Time/Part Time
Does CBD oil predispose to Neural Tube Defects? (Lab)
Gabriel Galea / Eirini Maniou
FT
The molecular and developmental basis of birth defects: a new model for cleft lip and palate (Lab)
Nicholas Greene / Zoe Crane-Smith
FT
Understanding the identity and differentiation potential of the amniotic fluid stem cells (Lab)
Mattia Gerli / Paolo De Coppi
FT
Development of a novel ex vivo model of congenital diaphragmatic hernia (lab)
Paolo De Coppi / Federica Michielin / Soichi Shibuya
The role of CYP26B1 in Coronary development (Lab)
Catherine Roberts / Nancy Stathopoulou
FT
Investigating cellular abnormalities in the brain in a novel mouse model of Non-Ketotic Hyperglycinemia (Lab)
Nicholas Greene / Sandra Castro
FT
Automatic 3D Face Alignment for CT scans using Generative Adversarial Network
Silvia Schievano / Athanasios Papaioannou
FT / PT
A skull 3D Morphable Model for young children
Silvia Schievano / Athanasios Papaioannou
FT / PT
Developing cell models and treatments for Usher syndrome using human pluripotent stem cells (Lab)
Jane Sowden / Leong Yeh Chwan
FT
Development of a novel xeno-free protocol to generate optic vesicles from human pluripotent stem cells (Lab)
Hassan Rashidi / Jane Sowden
FT
Gastric and intestinal organoid culture for tissue engineering, development, and disease modelling applications Paolo De Coppi / Giovanni Giuseppe Giobbe FT Understanding the underlying causes of primary microcephaly
Paula Alexandre / Andrew Copp
FT / PT
Exploring the role of extracellular matrix in the manifestation of semilunar valve defects in CXCL12/CXCR4 disrupted mice
Liam Ridge / Peter Scrambler
FT
- Developmental Neurosciences
Projects
Supervisors
Full Time/Part Time
ENLIVEN – Endoscopic Lavage after intraventricular haemorrhage in neonates
Kristian Aquilina / William Dawes
FT or PT
SOLVe (Sampling of Lateral Ventricle) Development of a human organotypic model to investigate the impact of intraventricular haemorrhage on brain development in the premature neonates (Lab)
William Dawes / Chris O'Callaghan
FT
Inducible CRISPRa human iPSC line as a cellular platform to investigate genes enhancing the myogenic capacity of human iPSC derived myoprogenitors (Lab)
Jennifer Morgan / Jinhong Meng
FT
Investigating the immune responses in gender dysphoria individuals on cross-hormone therapy (Lab)
Gary Butler / Coziana Ciurtin
FT
Exploring the emotional and psychosexual impact of cross-sex hormone treatment in transgender adolescents
Gary Butler
FT / PT
Biomarkers of response to ketogenic diets for drug-resistant epilepsy: carnitine ester changes and relationship to seizure outcomes
Christin Eltze / Steve Krywarwych /Natasha Schoeler
FT / PT
Long-term response to ketogenic diets for drug-resistant epilepsy
Natasha Schoeler / Christin Eltze / Helen Cross
FT / PT
- Genetic and Genomic Medicine
Projects
Supervisors
Full Time
Biomarker Discovery for Paediatric Hypertrophic Cardiomyopathy (Lab)
Wendy Heywood / Juan Pablo Kaski
FT
Development of a mass spectrometry method to measure cerebrosides in paediatric neurodegenerative disorders (Lab)
Wendy Heywood / Kevin Mills
FT
Lab project in Inborn Errors of Metabolism section contact administrator for title
FT
- Infection, Immunity and Inflammation
Projects
Supervisors
Full Time/Part Time
SOLVe (Sampling of Lateral Ventricle) Development of a human organotypic model to investigate the impact of intraventricular haemorrhage on brain development in the premature neonates (Lab)
William Dawes / Chris O'Callaghan
FT
Examining the role of physiotherapists in reducing the time to diagnosis of the Ehlers-Danlos syndromes and hypermobility spectrum disorders in children and adolescents in the UK
Jane Simmonds / Kay Julier
FT / PT
CRISPR/Cas9 targeted gene correction for Severe Combined Immunodeficiency caused by mutations in the IL7R gene Alessia Cavazza / Rajeev Rai FT Identification of reference gene expression in PBMCs from healthy volunteers and HIV+ patients; application in paediatric HIV cure studies (Lab)
Kathleen Gärtner / Eleni Nastouli
FT
Development of a base editing platform for genetic skin diseases using Netherton syndrome causative mutations as a prototype. Dr Evangelia Kounatidou / Dr Wei-Li Di FT Investigating the immune responses in gender dysphoria individuals on cross-hormone therapy (Lab)
Gary Butler / Coziana Ciurtin
FT
Skin graft gene therapy for genetic skin diseases - advances in in vitro cultivation of skin stem cells Dr Vignesh Jayarajan / Dr Wei-Li Di FT Quantifying triazole antifungal and immunosuppressant drug-drug interactions in haematopoietic stem cell transplant recipients: towards personalised immunosuppression
Joe Standing / Frank Kloprogge
FT / PT
- Population, Policy and Practice
Projects
Supervisors
Part Time
Health and other outcomes in children born to older mothers (a cohort of 33,000 children) Alastair Sutcliffe / Bev Botting PT Public attitudes towards human germline gene editing Dr Celine Lewis / Dr Sam Riedijik FT / PT Young People's experience of primary ciliary dyskinesia; a qualitative interview study Dr Celine Lewis / Hannah Mitchison FT / PT Impact of COVID-19 on health and wellbeing of children and young people with special educational needs and disability (SEND),
Newham, East London
Dr Michelle Heys / Dr Lee Hudson PT
Students may also develop a different project within the institute to those advertised.
Contact: mreschildhealth@ucl.ac.uk if you are interested in any of the projects above or to discuss the research project element of the MRes further.
