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MRes Research Projects

Research Projects available from Autumn 2020:

Developmental Biology and Cancer

Projects

Supervisors

 

Full Time/Part Time 

    

Does CBD oil predispose to Neural Tube Defects? (Lab)

Gabriel Galea / Eirini Maniou

 

FT 

The molecular and developmental basis of birth defects: a new model for cleft lip and palate (Lab)

Nicholas Greene / Zoe Crane-Smith

 

FT

    

Understanding the identity and differentiation potential of the amniotic fluid stem cells (Lab)

Mattia Gerli / Paolo De Coppi

 

FT

Development of a novel ex vivo model of congenital diaphragmatic hernia (lab)

Paolo De Coppi / Federica Michielin / Soichi Shibuya

 

 
    

The role of CYP26B1 in Coronary development (Lab)

Catherine Roberts / Nancy Stathopoulou

 

FT

    

Investigating cellular abnormalities in the brain in a novel mouse model of Non-Ketotic Hyperglycinemia (Lab)

Nicholas Greene / Sandra Castro

 

FT

    

Automatic 3D Face Alignment for CT scans using Generative Adversarial Network

Silvia Schievano / Athanasios Papaioannou

 

FT / PT

A skull 3D Morphable Model for young children

Silvia Schievano / Athanasios Papaioannou

 

FT / PT

Developing cell models and treatments for Usher syndrome using human pluripotent stem cells (Lab)

Jane Sowden / Leong Yeh Chwan

 

FT

Development of a novel xeno-free protocol to generate optic vesicles from human pluripotent stem cells (Lab)

Hassan Rashidi / Jane Sowden

 

FT 

Gastric and intestinal organoid culture for tissue engineering, development, and disease modelling applicationsPaolo De Coppi / Giovanni Giuseppe Giobbe FT
    

Understanding the underlying causes of primary microcephaly 

Paula Alexandre / Andrew Copp

 

FT / PT

Exploring the role of extracellular matrix in the manifestation of semilunar valve defects in CXCL12/CXCR4 disrupted mice

Liam Ridge / Peter Scrambler

 

FT

Developmental Neurosciences

Projects

Supervisors

 

Full Time/Part Time 

ENLIVEN – Endoscopic Lavage after intraventricular haemorrhage in neonates

Kristian Aquilina / William Dawes

 

FT or PT

SOLVe (Sampling of Lateral Ventricle) Development of a human organotypic model to investigate the impact of intraventricular haemorrhage on brain development in the premature neonates (Lab)

William Dawes / Chris O'Callaghan

 

FT

    

Inducible CRISPRa human iPSC line as a cellular platform to investigate genes enhancing the myogenic capacity of human iPSC derived myoprogenitors (Lab)

Jennifer Morgan / Jinhong Meng

 

 

FT

    

Investigating the immune responses in gender dysphoria individuals on cross-hormone therapy (Lab)

Gary Butler / Coziana Ciurtin

 

FT

    

Exploring the emotional and psychosexual impact of cross-sex hormone treatment in transgender adolescents

Gary Butler

 

FT / PT

Biomarkers of response to ketogenic diets for drug-resistant epilepsy: carnitine ester changes and relationship to seizure outcomes

Christin Eltze / Steve Krywarwych /Natasha Schoeler

 

FT / PT 

Long-term response to ketogenic diets for drug-resistant epilepsy

Natasha Schoeler / Christin Eltze / Helen Cross

 

FT / PT

Genetic and Genomic Medicine

Projects

Supervisors

 

Full Time 

    

Biomarker Discovery for Paediatric Hypertrophic Cardiomyopathy (Lab)

Wendy Heywood / Juan Pablo Kaski

 

FT 

Development of a mass spectrometry method to measure cerebrosides in paediatric neurodegenerative disorders (Lab)

Wendy Heywood / Kevin Mills

 

FT 

    

Lab project in Inborn Errors of Metabolism section contact administrator for title

 

 

FT 

Infection, Immunity and Inflammation

Projects

Supervisors

 

Full Time/Part Time 

    

SOLVe (Sampling of Lateral Ventricle) Development of a human organotypic model to investigate the impact of intraventricular haemorrhage on brain development in the premature neonates (Lab)

William Dawes / Chris O'Callaghan

 

FT

    

Examining the role of physiotherapists in reducing the time to diagnosis of the Ehlers-Danlos syndromes and hypermobility spectrum disorders in children and adolescents in the UK

Jane Simmonds / Kay Julier

 

FT / PT

CRISPR/Cas9 targeted gene correction for Severe Combined Immunodeficiency caused by mutations in the IL7R geneAlessia Cavazza / Rajeev Rai  FT
    

Identification of reference gene expression in PBMCs from healthy volunteers and HIV+ patients; application in paediatric HIV cure studies (Lab)

Kathleen Gärtner / Eleni Nastouli

 

FT 

Development of a base editing platform for genetic skin diseases using Netherton syndrome causative mutations as a prototype.Dr Evangelia Kounatidou / Dr Wei-Li Di FT
    

Investigating the immune responses in gender dysphoria individuals on cross-hormone therapy (Lab)

Gary Butler / Coziana Ciurtin

 

FT

Skin graft gene therapy for genetic skin diseases - advances in in vitro cultivation of skin stem cellsDr Vignesh Jayarajan / Dr Wei-Li Di FT
    

Quantifying triazole antifungal and immunosuppressant drug-drug interactions in haematopoietic stem cell transplant recipients: towards personalised immunosuppression 

Joe Standing / Frank Kloprogge 

 

FT / PT

 

 

 

 
Population, Policy and Practice

Projects

Supervisors

 

Part Time 

Health and other outcomes in children born to older mothers (a cohort of 33,000 children) Alastair Sutcliffe / Bev Botting PT

 

Public attitudes towards human germline gene editingDr Celine Lewis / Dr Sam Riedijik FT / PT
Young People's experience of primary ciliary dyskinesia; a qualitative interview studyDr Celine Lewis / Hannah Mitchison FT / PT

Impact of COVID-19 on health and wellbeing of children and young people with special educational needs and disability (SEND),

Newham, East London

Dr Michelle Heys / Dr Lee Hudson PT
   

 

Students may also develop a different project within the institute to those advertised. 

Contact: mreschildhealth@ucl.ac.uk if you are interested in any of the projects above or to discuss the research project element of the MRes further.