Professor Tim Cole developed the LMS method for constructing age-related reference ranges such as growth charts. The LMS method was used to develop the British 1990 growth reference, which was the official UK growth reference from 1996 to 2009.
The LMS method is now finding wider application, for example in the analysis of lung function in children and adults, or in levels and patterns of immunological and haematological markers in uninfected children of HIV infected mothers.
- Tim Cole
- Smoothing reference centile curves: the LMS method and penalized likelihood Statistics in Medicine 1992