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UCL Great Ormond Street Institute of Child Health

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Respiratory Physiology

Lead Contact: Dr Paul Aurora (p.aurora@ucl.ac.uk)

Joint Lead: Dr Gwyneth Davies (gwyneth.davies@ucl.ac.uk)

Introduction

The Respiratory Unit has an international reputation for the development and validation of lung function tests for use in infants and pre-school children, and the application of these measurements in epidemiological and clinical research studies. 

This has helped elucidate the early determinants of airway function and establish objective phenotypic outcome measures of the nature and severity of lung disease and response to therapy in a range of paediatric respiratory illnesses, including cystic fibrosis (CF), bronchopulmonary dysplasia, wheeze and sickle cell disease.

Aims

  • To develop and validate respiratory function tests for use in infants and young children
  • To apply these tests in clinical and epidemiological studies to strengthen the scientific basis for the prevention and treatment of respiratory disease in early life
  • To investigate the early determinants of lung growth and development in health and disease

Ongoing Research Collaboration

The London Cystic Fibrosis Collaboration