UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Infection, Immunity and Inflammation Programme

The III academic programme aims to deliver world class interdisciplinary research for children with infectious, immunological and inflammatory disease, children with life threatening respiratory disease, children in pain and critically ill children on intensive care.

Molecular basis of immunological and inflammatory disease: to apply high-throughput genetics and systematic deep phenotyping of patients to understand the molecular basis of these diseases.

Basic immunological mechanisms: to elucidate these mechanisms through experimentation in informative model systems and study of immunological development and function in children.

Pathogen action: to understand molecular mechanisms of pathogen action through study of microbial genetics and host response to challenge.

Disease prevention: to develop effective methods to enhance disease diagnosis in early childhood and utilise effective vaccination strategies.

Development of a world-leading translational research programme: to undertake clinical trials in children with immunological and inflammatory diseases using novel biologic agents, and cell and gene therapies

Respiratory, critical care & pain: to improve the understanding of early determinants of lung disease and the pathophysiology of children with life-threatening respiratory disease, critically ill children on intensive care and children in pain and to develop novel therapeutic and management strategies to improve their outcome.