Professor Sara Mole

People

• Jose Clemente Ramos (Research Associate)
• Christopher Minnis (Research Associate)
• Haoyu Zhang (PhD Student)

Collaborators

• Robin Ketteler (LMCB, UCL, UK)
• Chris Stefan (LMCB, UCL, UK)
• Robin Ali (KCL, UK)
• Ahad Rahim (SOP, UCL, UK)
• Paul Gissen (GOS ICH, UCL, UK)
• Mina Ryten (GOS ICH, UCL, UK)
• Tris McKay (Manchester Metropolitan University, UK)
• Thomas Wishart (Roslin Institute, UK)
• Emyr Lloyd-Evans (Cardiff University, UK)
• Andrew Quigley (Diamond Light Source, UK)
• Angela Schulz (University Medical Centre Hamburg-Eppendorf, Germany)
• Diego Medina (Telethon InsTitute of Genetics and Medicine, Italy)
• Juan Bolanos (University of Salamanca, Spain)
• Claire Russell (Royal Veterinary College, UK)
• Jonathan Cooper (Washington University, USA)

Funders

• Medical Research Council
• EU H2020 BATCure
• Wellcome Trust
• Children's Brain Disease Foundation USA
• Biomarin
• Batten Disease Family Association

Selected Publications

• Lopez-Fabuel I, et al (2022). Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis. Nat Commun 13(1):536. doi: 10.1038/s41467-022-28191-1
• Soldati S, et al (2021). Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype. EMBO Molecular Medicine, 13(10): e13742. doi: 10.15252/emmm.202013742
• Iwan K, et al (2021). Cerebrospinal fluid neurofilament light levels in CLN2 disease patients treated with enzyme replacement therapy normalise after two years on treatment. F1000Research 10(614). doi: 10.12688/f1000research.54556.1
• Minnis CJ, et al (2021). Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease. Scientific Reports. 11(1) 6332.  doi: 10.1038/s41598-021-85471-4
• SE Mole, et al (2021). Guidelines on the Diagnosis, Clinical Assessments, Treatment and Management for CLN2 Disease Patients. Orphanet J Rare Dis. 16(185). doi: 10.1186/s13023-021-01813-5
• Lourenço CM, et al (2020). Revealing the clinical phenotype of atypical neuronal ceroid lipofuscinosis type 2 disease: Insights from the largest cohort in the world. J Paediatr Child Health. 57: 519-525. doi: 10.1111/jpc.15250
• K Iwan, et al (2021). Urine proteomics analysis of patients with Neuronal Ceroid Lipofuscinoses. Iscience 24(2) 102020 doi: 10.1016/j.isci.2020.102020

Alumni

• Jaimie Greenham: Research Assistant/PhD student. Development and Technology Manager, Cellmark, UK. 1994-1997
• Treasa Creavin: PhD student. Scientific Programme Development, Wellcome Genome Campus Advanced Courses and Scientific Conferences, Birkbeck, University of London, UK. 1994-1997
• Wayne Mitchell: PhD student. Researcher at Imperial Innovations, UK. 1997-2000
• Morwenna Porter: PhD student. Portfolio Eligibility Facilitator, NIHR Clinical Research Network, UK. 2000-2003
• Yella Martin: PhD student. HCP Editor, Medical News Today. 2000-2006
• Rebecca Haines: PhD student. NHS clinical scientist in Bioinformatics, Nottingham, UK. 2005-2008
• Mariana Vieria: PhD student. Investigator, Universidade da Madeira, Madeira. 2010-2013
• Davide Marotta: PhD student. Scientist, The Institute of Cancer Research, UK. 2011-2014
• Sophie Kleine Holthaus: PhD student. Postdoc, UCL Institute of Ophthalmology, UK. 2012-2015
• Rachel Brown: PhD student. International Policy Officer, The Academy of Medical Sciences, UK. 2012-2015
• Christopher Minnis: PhD student. Research Associate, UCL GOSH Institute of Child Health. 2016-2019
• Yaxuan Lyu: PhD student. 2017-2021
• Hannah Mitchison: Research Associate. Head of Department, UCL GOSH Institute of Child Health, Genetics and Genomics Department. 1992-1998
• Patricia Munroe: Research Associate. Professor of Molecular Medicine, St Bartholomew’s and The London School of Medicine and Dentistry, UK. 1993-1998
• Kit-Yi Leung: Research Associate. Lecturer, St Bartholomew’s and The London School of Medicine and Dentistry, UK. 1997-2001
• Julie Sharp: Research Associate. Head of Health & Patient Information, CRUK, UK. 1994-2002
• Ruth Wheeler: Research Associate. Clinical Laboratory Scientist, Viapath LLP, St Thomas’ Hospital, UK. 1993-2002
• Sandra Codlin: Research Associate. Biosciences Teaching Laboratory Manager, Birkbeck, University of London, UK. 2002-2009
• Claudia Kitzmuller: Research Associate. Medizinische Universitaet Wien (General Hospital Vienna), Austria. 2004-2008
• Michael Bond: Research Associate. MRC Technology, UK. 2001-2014
• Julia Petschnigg: Research Associate. 2016-2017
• Sophia kleine Holthaus: Research Associate. 2015-2019
• Mikel Aristorena: Research Associate. 2016-2021
• Elisa Tinelli: Research Associate. 2015-2020

Sara Mole CV

• 2018 to date: UCL Envoy for Gender Equality
• 2018 to date: UCL GOS Institute for Child Health Section Head for Inborn Errors of Metabolism
• 2017-2020: Great Ormond Street Hospital Children’s Charity Professor
• 2016: Professor in Molecular Cell Biology, UCL
• 2005: Reader in Molecular Cell Biology, UCL
• 2004-2022: Group Leader, MRC Laboratory for Molecular Cell Biology
• 1997-2005: Senior Lecturer in Molecular Genetics, Department of Paediatrics, UCL
• 1992-1997: Lecturer in Molecular Genetics, Department of Paediatrics, University College London
• 1989-1992: Postdoctoral Research Associate, University of Cambridge, UK
• 1986-1989: Postdoctoral Fellow, Imperial Cancer Research Fund, UK
• 1983-1986: PhD, Biochemistry, Imperial College London, UK
• 1980-1983: BA (Hons) Natural Sciences, University of Cambridge, UK

Awards

• 2018: UCL Provost’s Prize for Excellence (Equality, Diversity, Inclusion)
• 2013: UCL Provost’s Prize for Public Engagement (Senior Staff)
• 2012: Batten Disease Family Association Board of Trustees Award
• 2009: “Highly commended” in Provost’s First Public Engagement Award

Technology

• Light microscopy
• Translational research
• Bioinformatics
• Electron microscopy
• Microbiology
• RNA deep sequencing