UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Professor Paul Gissen


The Gissen group use cell and molecular biology approaches to investigate rare genetic disorders with a focus on abnormalities of intracellular trafficking and develop novel therapies to treat these disorders.

Our long-standing interest is in understanding the mechanism of function of a multi-protein tethering complex containing VPS33B and VIPAR. Defects in these two proteins cause a multi-system human disorder Arthrogryposis, Renal Dysfunction and Cholestasis Syndrome (ARC). For this work and other studies we employ cell and animal models of human disease including patient-derived induced pluripotent stem cells (iPSc) that can undergo differentiation into a variety of highly specialised cell types.