UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Dr Sergi Castellano

Research People Collaborators Publications Commentaries Outreach Teaching


We are always looking for motivated students and researchers at all levels. Contact me (s.castellano@ucl.ac.uk) if you are considering applying to a fellowship to join our group. Check also current open positions below.

Come work to London!

MRC Postdoctoral position: Epithelial sheet gene therapy for genetic skin diseases

We have performed a gene therapy trial for a debilitating genetic skin disease, in which gene corrected patient skin derived keratinocytes, including keratinocyte stem cells, were cultured as skin-like sheets and grafted back onto the patients. The outcomes of this gene therapy are encouraging but the prolonged stem cell culture required impedes its wide therapeutic application. In this project, we propose to treat keratinocytes with a drug to speed up the growth of keratinocyte stem cells, assess their characteristics using single-cell sequencing and bioinformatics approaches, and demonstrate the safety of rapid epithelial sheet gene therapy.

Informal inquires can be sent to Wei-li Di at w.di@ucl.ac.uk and Sergi Castellano at s.castellano@ucl.ac.uk.