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Dr Sergi Castellano

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Jobs

We are always looking for motivated students and researchers at all levels. Contact me (s.castellano@ucl.ac.uk) if you are considering applying to a fellowship to join our group. Check also current open positions below.

Come work to London!

AMS Postdoctoral position: single-cell approaches to cancer stem cells

We are seeking a talented and highly motivated computational biology postdoc to join the research group of Dr Alice Giustacchini at the Great Ormond Street Institute of Child Health at UCL, within the Section of Molecular and Cellular Immunology and will benefit from the co-supervision of Dr Sergi Castellano, Head of the Genome Biology and Precision Medicine section. The successful candidate will lead the analysis and interpretation of single cell RNAseq data, with the aim of unravelling a distinct molecular signature predictive of therapy resistance and disease progression in myeloid leukaemia. This post is funded for 24 months in the first instance. See details here.

Informal inquires can be sent to Alice Giustacchini at a.giustacchini@ucl.ac.uk and Sergi Castellano at s.castellano@ucl.ac.uk.

MRC Postdoctoral position: Epithelial sheet gene therapy for genetic skin diseases

We have performed a gene therapy trial for a debilitating genetic skin disease, in which gene corrected patient skin derived keratinocytes, including keratinocyte stem cells, were cultured as skin-like sheets and grafted back onto the patients. The outcomes of this gene therapy are encouraging but the prolonged stem cell culture required impedes its wide therapeutic application. In this project, we propose to treat keratinocytes with a drug to speed up the growth of keratinocyte stem cells, assess their characteristics using single-cell sequencing and bioinformatics approaches, and demonstrate the safety of rapid epithelial sheet gene therapy. This post is funded for 24 months in the first instance.

Informal inquires can be sent to Wei-li Di at w.di@ucl.ac.uk and Sergi Castellano at s.castellano@ucl.ac.uk.