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UCL Great Ormond Street Institute of Child Health

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Prof Tom Jacques

Prof Tom Jacques

Professor of Paediatric Neuropathology

Developmental Biology & Cancer Dept

UCL GOS Institute of Child Health

Joined UCL
6th Dec 2004

Research summary

The aim of our group is to understand the development of paediatric brain diseases and in particular the roles of neural stem cells in these diseases. We have focussed on brain tumours and epilepsy. Recent highlights include demonstrating how initial mutations cause different types of tumour in the brain and the isolation of a pathological stem cell from a human malformation of cortical development.

Keywords: Brain, Brain Tumour, Cancer, Epilepsy,  Focal Cortical Dysplasia, Morphology, Neural stem cells, Neuroanatomy, Neurogenesis,Neuropathology, Progenitors, Stem cells, Temporal lobes

Conditions: Astrocytoma, Brain tumours in children, Focal Cortical Dysplasia, Epilepsy

Methods: Cell culture, Confocal microscopy, Gene expression profiling - tissue level, Histology, Immunohistochemistry, light microscopic techniques, Time-lapse imaging, Stereological analysis

Education

Royal College of Pathologists, UK
FRCPath, Neuropathology | 2008
Royal College of Pathologists, UK
MRCPath, Neuropathology | 2007
Royal College of Physicians
MRCP, Medicine | 2000
University of Cambridge
PhD, Neuroscience | 1998
University of Cambridge
MB BCh, Medicine/Surgery | 1997
University of Cambridge
MA, Clinical Medicine | 1996
University of Cambridge
BA, Medical Sciences | 1992
Publications