UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health

Prof Alastair Sutcliffe

Prof Alastair Sutcliffe

Professor of General Paediatrics

Population, Policy & Practice Dept

UCL GOS Institute of Child Health

Joined UCL
1st Jan 2002

Research summary

I have conducted studies in outcomes of early life since 1993, these include the first on outcome of embryo cryopreservation, PGD and twin twin transfusion syndrome.These studies continue, with the first on Oocyte cryopreservation outcome, and PCOS outcome studies.

I have conducted two cancer epidemiology studies, one to estimate the risk of cancer in women treated with ART (Assisted Reproductive Therapies) and also separately child cancer risk.

I recently completed a major and innovative a study investigating health in children born to older Mothers.

I was chief investigator in a randomized controlled trial to determine the effect of frenotomy on tongue tied breast fed infants.

I am chief investigator on a study which will establish a secure means of identifying acholuric stools.

With Belgian collaborators we  investigated epigentic risk in ART conceived UK teenagers.

I am also a member of the STOP consortium http://www.stop-study.com/ whose brief is to assess suicidality risk in children exposed to certain medicines such as SSRI's and Montelukast.

I lead to Bench two Bedside projects, the first is in collaboration with Dr Alastair Baker and Professor Long Lin. It aims to develop a screening tool to allow early recognition of Biliary Atresia and other obstructive liver diseases of neonatal life.

The second is in its early stages but aims to develop a preventive treatment for premature labour caused by  ascending infection. This is in collaborations with Professors Paul Long, Dr Jude Oben and Dr Paul Hardiman. We will patent our pessary at the end of 2019

I have  a major role in medicines for children and am conducting research involving pharmacovigilance. I am presently a member of the WEB-RADR consortium led by the MHRA and funded by the EU which will improve Pharmacy vigilance reporting across the EU via an IMI grant.

I am leading a study using National Pupil Database data to investigate the educational prospects of children treated for cancer in childhood.

A summary of my research efforts around Assisted reproductive therapies was given in an interview with Chris Jones from the Faculty of Health and Social Care at Edge Hill University, which can be viewed at http://www.eshare.edgehill.ac.uk/4971/1/index.html

My present reseach in ART outcomes is funded by the Wellcome Foundation until 2023.

Teaching summary

Commended Teacher UCLH 2009-10

Excellence in Medical Education Awards 2008

Top Teacher 2007-8





Vrije Universiteit Brussel
Doctorate, Doctor of Philosophy | 2008
London School of Hygiene and Tropical Medicine
Other Postgraduate qualification (including professional), Postgraduate Diploma in Controlled Trials | 2008
University of London
Doctorate, Doctor of Medicine | 2000
Royal College of Paediatrics and Child Health
Doctorate, Fellow of the Royal College of Paediatrics and Child Health | 1997
Royal College of Physicians
Doctorate, Fellow of the Royal College of Physicians | 1992
University of Manchester
Doctorate, Bachelor of Medicine, Bachelor of Surgery | 1987


1.     ART outcome/late effects work Since 1993 I have been studying paediatric outcomes of IVF, starting with the first study on the child outcome of embryo cryopreservation in Manchester University. After coming to Royal Free Medical School I initiated a National Study of some of the first ICSI born children in the UK (at 18 months of age.)  This is ongoing since 1996 y. At aged 5 years these children were studied with four other countries in Europe in a 1,550 child study comparing ICSI-IVF and spontaneously conceived children. Funded by an EU 5th framework grant (I was PI) it is the largest detailed study of ART children to date. Other outcome studies I have led include the first to investigate outcome of Twin Twin transfusion syndrome treatment by laser cryoptherapy with Professor Kypros Nicolaides. In 2010 An unprecedented opportunity arose to conduct much more robust studies of ART outcome. This is by linkage of the HFEA registry data to other datasets now possible due to the then new HFEA act of parliament 2010. I was funded by Cancer Research UK (with inter alia Professor Ian Jacobs) to investigate if the > 200,000 women exposed to 720,000 ART treatment cycles since 1990 are at higher risk of cancer or death, via linkage to the NHS-Information Service. I have also obtained a recent Wellcome Individual Clinician Award which are prestigious and recognises my work in this arena.