Prof Gudrun Moore
Professor of Clinical and Molecular Genetics
ICH Genetics & Genomic Medicine Prog
UCL GOS Institute of Child Health
- Joined UCL
- 1st Jan 2006
Professor Gudrun Moore research interests include the genetic aetiology of complications of pregnancy focussing on fetal growth restriction (FGR). Professor Moore and her group have been studying the role of imprinted genes in the aetiology of growth restriction since 1995 and have made many interesting links with genes that are imprinted and growth and development. Professor Moore's research team includes five post-doctoral fellows; a biobank Manager; one clinical fellow and two PhD students. Other research areas include: the establishment and maintenance of the mechanisms of imprinted genes in human stem cells; the role of biomarkers in FGR and the assessment of imprinting in the human placenta. The research group also has a strong interest in the genetic aetiology of recurrent miscarriage and complications of pregnancy. Funded by Wellbeing of Women and in collaboration with Professor Lesley Regan at Imperial College London, Professor Moore has set up a bioresource of complications of pregnancy, the Baby Bio Bank. Over 2500 trios (mother father and baby) have contributed, each trio with biosamples and over 280 fields of medical data. The Baby Bio Bank was opened to researchers in 2013.
Current research projects:
The role of imprinted genes and methylation profiles in fetal growth, Silver-Russell syndrome,
human reproduction and dysmorphologies.
The role of H19/IGF2 imprinting pathway in intrauterine growth restriction.
Studying rare disease genes important in intellectual disability
Analysing human imprinted genes in the placenta.
Professor Moore is Director of the UCL Genetics Institute MSc in Genetics of Human Disease which started in 2009.
- University of Hull
- PhD, Zoology | 1982
- University of York
- BA, Biology | 1978
Professor Gudrun Moore has made an outstanding, internationally-acclaimed contribution to the molecular genetics of major complications of pregnancy: fetal growth restriction (FGR), pre-eclampsia, miscarriage, and fetal malformation, particularly cleft palate (Nature1987; Nature Genetics 2001;) and most recently the somatic gene mutation for Congenital melanocytic naevi (JID 2013) and Lenz-Majewski syndrome (Nature Genetics 2014).
She has applied genetic and epigenetic techniques to the study of FGR using Silver Russell syndrome (SRS) as an exemplar. This research approach led to the discovery of maternal uniparental disomy for human chromosome 16 and 7 in placental mosaic 16 pregnancies and SRS respectively (Lancet 1992). By 2000 these findings had been translated into NHS diagnostic tests, antenatally for mosaic 16 pregnancies and postnatally for SRS families. Her finding of limited conservation of genomic imprinting between mice and humans in placental gene expression is another major advance in the reproductive field. (PNAS, 2006). This has demonstrated that studies in humans are vital for a complete picture of the evolutionary consequences of genomic imprinting as it relates to human disease particularly birth weight health outcomes (AJHG 2012). Equally important has been her investigation of the role of biomarkers for pre-eclampsia and recurrent miscarriage (Nature Genetics 2007; JCI 2010).
Her unique contribution to maternal, fetal and child health will be recognised for years to come through her establishment of the Wellbeing-of-Women-funded “Baby Bio Bank” with Professor Regan (Imperial College London) which opened to researchers November 2013. This national epidemiological and biological resource will facilitate research into complications of pregnancy, enabling development of new diagnostic and therapeutic measures.
She is an inspirational leader and a natural communicator and speaks regularly to lay audiences. She is currently job sharing as UCL Pro vice Provost (International), directs an UCL MSc in the Genetics of Human Disease and is Chief Scientific Advisor for the Children’s medical charity, Sparks.