UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Prof Christopher O'Callaghan

Professor of Respiratory and Paediatric Medicine

ICH Infect, Imm, Infla. & Physio Med

UCL GOS Institute of Child Health

Joined UCL
18th Jun 2012

Research summary

Major interest is in conducting basic laboratory research that translates directly into patient benefit.  
Currently leading projects on the development of novel drug delivery devices for which he holds the patent, to develop novel devices and and adherence devices for clinical use. Prototype development is funded by industry with the aim to launch products in 2019.  Was lead on the patent for antistatic use on drug delivery devices filled by the University of Melbourne.  Held a ëSeeding Drug Discovery (£3.5 million) grant from the Wellcome Trust with two co-researchers that successfully developed a small molecule to block the pneumococcal toxin, pneumolysin.   Developed a novel anti-RSV drug that has been patented and is currently being explored. Currently working leading work on a novel antibiotic compound, that has excellent activity against non-tuberculous mycobacterial infections.  
Runs two laboratories that are internationally recognised for research into the ciliated epithelium and aerosol drug delivery. The UCL Great Ormond Street Institute of Child Health laboratory focuses on infection of the ciliated respiratory epithelium and respiratory disease and the development of novel therapies to protect and restore epithelial function. Has developed novel methods that allow relatively high throughput screening of novel therapies on ciliated epithelium grown from single biopsies from the respiratory tract of children and adults with both common and rare disease. Established a ëLiving Airway Biobank of respiratory epithelium from children and adults with respiratory disease.   The laboratory he leads at the University of Leicester is dedicated to research into Primary Ciliary Dyskinesia diagnostic and therapeutic approaches and clinical diagnostic testing. The laboratories work closely together on projects aimed at overcoming nonsense mutations that are responsible for approximately one third of PCD patients. 

Teaching summary

Awarded the Principal Fellowship of the Higher Education Academy(PFHEA) in 2018 for international work focused on the production, delivery and assessment of multimedia education for health workers. 
Awarded the Imu-Ron Harden Innovation in Medical Education (IMU) prize in 2016
Founder of World Medical Education (2016) - a not for profit social enterprise. 
Has published seventeen books/multimedia programs relating to medical education and respiratory disease. 
World Medical Education, is dedicated to the video intense multimedia education of health workers worldwide with a particular focus on those working in the resource poor countries of Africa and South East Asia.
The website and delivery platform for World Medical Education can be seen at:
Current projects are supported by: 
   The World Health Organisation
   Save the Children
   The Fred Hollows Foundation
   The Chalker Foundation

Aims of World Medical Eduction:

Presence: to provide open access multimedia training to all health workers worldwide, whether they work in the remotest areas or in major hospitals.
Quality: to work with medical experts, health workers, patients, families and communities to ensure our educational programs are of the highest quality; and to research the clinical impact of programs developed.
Sustainability: to innovate and develop sustainable income streams to allow constant development and improvement of our educational programs through learner engagement, feedback and research.

About our group: 
Over the last 18 years the founding members have produced over 100 multimedia educational resources for health professionals and have been the recipients of awards for excellence in healthcare education on many occasions. Recent projects include: Ophthalmology, A Global Multimedia Guide, Clinical Skills in ENT, Minor Injuries in A&E and Clinical Examination for Students. We are now bringing this expertise together in a not-for-profit social enterprise which will develop educational materials across the spectrum of medicine and surgery, providing a sustainable resource for health workers worldwide.


Professor of Respiratory and Paediatric Medicine, Head of Respiratory, Critical Care and Anaesthesia and Translational Research Lead, UCL Great Ormond Street Hospital Institute of Child Health. 
Founder and current director of the not for profit organisation World Medical Education www.worldmedicaleducation.org  https://learning.worldmedicaleducation.org
Honorary Professor of Paediatrics Beijing Children’s Hospital, Capital Medical University and China’s National Research for Respiratory Disease.  Visiting Professor Hong Kong University.
Advisor to the World Health Organisation in the fields of Maternal and Child Health and Deafness and Hearing loss.
Works clinically half time with the rest of his time dedicated to Research and Education. Has extensive experience in Respiratory and acute General Paediatrics. Developed the national diagnostic service for PCD and leads a national diagnostic laboratory.

PFHEA            Principal Fellowship of the Higher Education Academy
PhD                 Doctor of Philosophy (Brain cilia) 
DM                  Doctorate of Medicine (Aerosol drug delivery) 
FRSB              Fellow of the Royal Society of Biology
FRCPCH         Fellow of the Royal College of Paediatrics and Child Health
FRCP              Fellow of the Royal College of Physicians
BM, BS            Bachelor of Medicine and Surgery (Nottingham University)
BMedSci          Bachelor of Medical Sciences