UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Prof Chris Clark

Professor of Imaging and Biophysics

Developmental Neurosciences Dept

UCL GOS Institute of Child Health

Joined UCL
1st Feb 2006

Research summary

My research focus is on the development and application of diffusion tensor imaging (DTI) and tractography for the understanding of neurological disability. Tractography uniquely allows the mapping of the white matter tracts of the living human brain. These methods can be used to reconstruct a wide range of clinically eloquent tracts such as the cortico-spinal tracts, fornix, optic radiations and uncinate fasciculus among others. A particular theme of research in which I have been active is the development of these methods for the purposes of neurosurgical planning in both children and adults. I am also using these methods to investigate the relationship between white matter damage and post-surgical deficits. I am leading a number of research projects both on the development of tractography methods, using for example Markov Chain Monte Carlo methods, as well as a wide range of clinical studies in children focused on epilepsy (temporal lobe epilepsy, febrile convulsions, infantile spasm) and brain tumour diagnosis and collaborate with colleagues on studies in developmental amnesia. I am also actively participating in adult studies of stroke recovery and early white matter damage in familial Alzheimer’s disease.


University College London
Doctorate, Doctor of Philosophy | 1998
University College London
Other higher degree, Master of Science | 1994
University College London
First Degree, Bachelor of Science | 1990