UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Otto Wolff Lecture of the Infection, Immunity and Inflammation Programme Symposium

30 May 2019, 9:00 am–5:00 pm

Keynote lecture of the Infection, Immunity and Inflammation Programme Symposium on 30th May 2019 "Clearing out Muco-Obstruction from the Distal Airways duing Viral Bronchiolitis

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Director's office, UCL GOS ICH
+44 (0) 207 905 2189


Leolin Price Lecture Theatre
UCL Great Ormond Street Institute of Child Health
30 Guilford Street

Keynote speaker: Professor Raymond Pickles, Marsico Lung Institute, University of North Carolina

Professor Pickles's laboratory, is located at the Cystic Fibrosis/Pulmonary Research and Treatment Center in the Thurston-Bowles building at UNC. They are interested in respiratory virus infection of the lung. This research has two major goals:

  1. To develop a better understanding of how common respiratory viruses infect the lung and how cell-type tropism and innate immune factors influence the pathophysiological consequences of viral infection especially in individuals with underlying lung diseases such as cystic fibrosis (CF) and Chronic Obstructive Pulmonary Disease (COPD).
  2. To exploit the mechanisms that respiratory viruses have evolved to infect respiratory epithelium for the development of strategies to deliver therapeutic transgenes to the airways of patients with diseases such as cystic fibrosis.

Currently, they are focused on the following common respiratory viral pathogens: influenza viruses (human and avian); respiratory syncytial virus (RSV); and parainfluenza viruses (PIV) since these viruses are amongst the most common cause of viral infections in infants and children and have high incidence of morbidity in patients with chronic lung disease.

They use in vitro and in vivo models to test factors that influence the extent and duration of virus infection and what inflammatory consequences occur after infection of the epithelial cells of the lung. They are especially interested in the altered environment of the inflamed lung and how this environment may affect the infection and consequences of infection by respiratory viruses.


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