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Current PhD vacancies are listed below. See the postgraduate pages for more information on our PhD programmes

A 3-year UCL-Hexcel Studentship in Multiscale Modelling and Simulation of Graphene and Graphene-Oxide Polymer Composites (D/L:20/12/19)

Supervisor: Professor P V Coveney, UCL

Start date: January 2020


UCL in collaboration with Hexcel (http://www.hexcel.com) are offering a studentship to a highly motivated candidate to start in January 2020. The studentship will cover tuition fees at UK/EU rate, a tax-free stipend (£17009 for 2019/2020) and around £2,000 pa support grant to cover additional costs such as training courses, conferences, visits to collaborators, field work, etc. The studentship offers a placement within Hexcel of at least 3 months as well as supervisory input from the company.

 

The student will develop and implement multiscale modelling methodologies to investigate polymer nanocomposites with particular focus on epoxy-resins. These composite materials are expected to exhibit properties of importance to aerospace industries owing to their anticipated properties (lightweight, strong, durable, as well as being environmentally friendly and sustainable). While the student will need to perform some amount of electronic structure calculations in order to extract key parameters pertaining to charge distributions and dispersion interactions, the focus of their work will be on a combination of modelling methods at the level of classical molecular dynamics (both all atom and coarse-grained) and its connections to higher levels of modelling in order to make predictions of large-scale materials properties.

 

Hexcel, whose laboratories are in close proximity to UCL, will perform a range of performance tests on the same materials as the student will be modelling, thereby providing experimental validation of the theoretical and simulation work.

 

A central objective in this work is to this work is to assess the accuracy, precision, and reliability of such computer-based predictions of the properties of these nanomaterials. The overarching goal is to make high-fidelity, chemically-specific predictions of the mesoscale structure from the nanoscale description of these composites, and, in turn, to predict emergent macroscopic behaviour and properties.

 

Applicants should have, or be expecting to achieve, a first or upper-second class honours degree or equivalent in physics, chemistry or a related subject and must be able to demonstrate significant computational experience including use of high-level programming languages (such as Fortran, C/C++, and Python or other scripting methods).

 

Interested candidates should contact p.v.coveney@ucl.ac.uk with a degree transcript and a motivation letter explaining their interest in this project. Informal enquiries are encouraged, and applications are accepted until a suitable candidate is identified, and before January 2020.

 

Due to funding restrictions, the proposed student must be a UK or EU national and have lived in the UK for the previous 3 years (for either work or education).

A 3-year Studentship in Laser Photoelectron Spectroscopy of Bioluminescence Emitters (D/L:28/02/20)

Supervisor: Professor H H Fielding, UCL

Start date: September 2020


We have a vacancy for a PhD student to join our group working on a new EPSRC-funded project to develop a molecular-level understanding of bioluminescence for the rational design of new bioluminescence tools for multicolor, deep-tissue imaging. The PhD project will involve carrying out photoelectron spectroscopy (PES) and femtosecond time-resolved PES measurements on isolated bioluminescent emitters in the gas-phase and in a liquid-microjet to determine the role of aqueous and biological environments on the electronic structure and electronic relaxation dynamics following photoexcitation. It will also involve carrying out computational chemistry calculations to assist with the interpretation of the experimental measurements. This project will form part of an interdisciplinary feedback loop between spectroscopy, computational chemistry and synthesis, led by Professors Helen Fielding, Graham Worth and Jim Anderson). 

 

Applicants should have, or be expecting to achieve, a first or upper-second class honours degree or equivalent in chemistry, physics or a related subject and must be able to demonstrate strong interest and enthusiasm for spectroscopy and quantum chemistry. They must also have effective written and verbal communication skills in English. The studentship will cover tuition fees at the UK/EU rate plus a maintenance stipend for three years (standard maintenance stipend for the academic year 2019/2020 is £17009).

 

Interested candidates should contact h.h.fielding@ucl.ac.uk with a degree transcript and a motivation letter explaining their interest in this project. Informal enquiries are encouraged, and applications are accepted until a suitable candidate is identified, and before March 2020. Informal inquiries are encouraged.  Suitable candidates will be required to complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply. Any admissions queries should be directed to Dr Jadranka Butorac (j.butorac@ucl.ac.uk).

 

Two 3-year PhD studentships in Organic Chemistry (D/L:31/01/20)

Supervisor: Professor Matthew Powner, UCL

Start date: 01 October 2020

 

Applications are invited from suitably qualified candidates for two three-year PhD Studentships. The studentships are fully funded by the Simons Foundation and available from January 2020, depending on applicant availability. The successful candidates will be based in the Department of Chemistry at UCL and supervised by Prof. Matthew Powner.

The overall project goal is to explore the chemical origins of life. Robust chemical reactions will be developed to explore the relationship predisposed chemistry and the origins of life. The work will involve developing of novel multicomponent reactivity and exploit nitrile reactivity, extending recently reported work from our group (Nature 2019, 571, 546–549; Nat. Commun. 2018, 9, 4073; Nat. Commun. 2017, 8, 15270; Nat. Chem. 2017, 9, 584–589; J. Am. Chem. Soc. 2012, 134, 13889; J. Am. Chem. Soc. 2010, 132, 16677).

This is an exciting opportunity for students with a strong chemistry background to tackle one the biggest problem in Science. The successful applicants will join a highly motivated group working at the interface of organic and biological chemistry to elucidate the chemistry that underpins the Origins of Life on Earth.

The postholders will be required to carry out chemical research into the synthesis and function of biological and biomimetic molecules in water. The postholder will contribute to the design and implementation of research strategy, and provide full records, analyses and internal reports of all research outcomes.  

Prof. Powner is an Investigator of the Simons Foundation (New York, USA), and a broad range of international collaborative interactions are on-going within Simons Foundation Collaboration on the Origins of Life (www.simonsfoundation.org/life-sciences/origins-of-life/simons-collaborat...). The minimum requirement is a first class or upper second-class honours degree (MSci, MChem) or equivalent.

Applications, including a cover letter and full and up-to-date CV, together with the names, addresses and email addresses of two academic referees should be sent as soon as possible to Prof. Powner (matthew.powner@ucl.ac.uk). Informal inquiries may be made with Prof. Powner, but suitable candidates must all complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply.

Any admissions queries should be directed to Dr Jadranka Butorac (j.butorac@ucl.ac.uk). The deadline for applications is 5 p.m. UK time on Friday 31st January 2020, but the position will be filled as soon as a suitable candidate has been identified. The applicants should have, or be expecting to achieve, a first or upper second class Honours degree in Chemistry (or equivalent).

Due to funding restrictions, this studentship is only open to applicants from the UK and EU, or students who have indefinite leave to remain in the UK.

 

3-year PhD studentship in Organic Chemistry (D/L:31/01/20)

Supervisor: Professor Matthew Powner, UCL

Latest start date: 01 September 2020

 

Applications are invited from suitably qualified candidates for a three-year PhD Studentship. The Studentship is fully funded by the Leverhulme Trust and is available from March 2020, depending on applicant availability. The successful candidate will be based in the Department of Chemistry at UCL and supervised by Prof. Matthew Powner.

The overall project goal is to explore the chemical origins of nucleic acids. Robust chemical reactions will be developed to explore the relationship predisposed chemistry and the origins of nucleic acids. The work will involve developing of novel multicomponent reactivity and exploit nitrile reactivity, extending recently reported work from our group (Nature 2019, 571, 546–549; Nat. Commun. 2018, 9, 4073; Nat. Commun. 2017, 8, 15270; Nat. Chem. 2017, 9, 584–589; J. Am. Chem. Soc. 2012, 134, 13889; J. Am. Chem. Soc. 2010, 132, 16677).

This is an exciting opportunity for a student with a strong chemistry background to tackle one the biggest problem in Science. The successful applicant will join a highly motivated group working at the interface of organic and biological chemistry to elucidate the chemistry that underpins the Origins of Life on Earth.

The postholder will be required to carry out chemical research into the synthesis and function of biological and biomimetic molecules in water. The postholder will contribute to the design and implementation of research strategy, and provide full records, analyses and internal reports of all research outcomes.  

Prof. Powner is an Investigator of the Simons Foundation (New York, USA), and a broad range of international collaborative interactions are on-going within Simons Foundation Collaboration on the Origins of Life (www.simonsfoundation.org/life-sciences/origins-of-life/simons-collaborat...). The minimum requirement is a first class or upper second-class honours degree (MSci, MChem) or equivalent.

Applications, including a cover letter explaining the candidate motivation and full and up-to-date CV, together with the names, addresses and email addresses of two academic referees should be sent as soon as possible to Prof. Powner (matthew.powner@ucl.ac.uk). Informal inquiries may be made with Prof. Powner, but suitable candidates must all complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply.

Any admissions queries should be directed to Dr Jadranka Butorac (j.butorac@ucl.ac.uk). The deadline for applications is 5 p.m. UK time on Friday 31st January 2020, but the position will be filled as soon as a suitable candidate has been identified. The applicants should have, or be expecting to achieve, a first or upper second class Honours degree in Chemistry (or equivalent).

Due to funding restrictions, this studentship is only open to applicants from the UK and EU, or students who have indefinite leave to remain in the UK.

 

BBSRC funded studentship in Selective methylation and alkylation using methyl transferases (D/L:24/01/20)

The overall aim of the PhD is to develop the use of methyl transferase enzymes in selective alkylation reactions and to construct novel enzyme cascades for the sustainable synthesis of structurally diverse compounds. Methyl groups can have a significant beneficial effect on the physicochemical and biological properties of bioactive compounds [1]. However, it is very difficult to achieve selective methylation reactions using traditional synthetic approaches and typically, toxic reagents such as methyl iodide are used. Enzymatic methylation provides a very valuable alternative method using methyl transferases (MTs) which have received comparatively little attention to date in biocatalytic syntheses [2]. They are particularly useful enzymes for the regioselective methylation of compounds as well as the diversification of compound libraries. In recent work we have started to investigate the cloning and use of MTs as well as generating the expensive co-factor S-adenosyl methionine (SAM) in situ using methionine adenosyltransferases (MATs) [2-4].

In this interdisciplinary project we will develop MTs and cofactor supply systems in enzymatic reaction cascades with a range of compounds for the selective methylation of O-, N- and C-groups. In addition, we aim to integrate the in situ alkylation of enzymatically generated hydroxyl or amino groups formed via other enzymes to ensure the construction of highly integrated new reaction cascades towards heterocyclic compounds using SAM and SAM analogues. Initially MTs will be used in biocatalytic methylations with heterocyclic substrates such as alkaloids [5], as well as alcohols and amines, to establish regio- and stereoselectivities. Other enzymes will also be incorporated to produce amines [6], alcohols or alkaloids [7] in situ with a view to establishing novel enzyme cascades. In addition, new MTs will be discovered using metagenomic and bioinformatics strategies. If required MT mutagenesis will be carried out to enhance enzyme performance. In the final year, building upon successful results, extension to other enzyme cascades and a reaction scale-up will be explored together with a placement (minimum 3 months) at Almac Sciences.

This iCASE BBSRC PhD studentship is a collaboration between Professor Helen Hailes’ and Prof John Ward’s groups at UCL and also Almac Sciences (https://www.ucl.ac.uk/chemistry/people/professor-helen-c-hailes; https://www.almacgroup.com/api-chemical-development/biocatalysis-solutions/). Applicants must hold, or be expected to achieve, a first or high upper second-class undergraduate honours degree or equivalent (for example BA, BSc, MSci) degree in Chemistry, Chemical Biology or a related discipline. They should be self-motivated, be keen to work on a collaborative interdisciplinary project with industry and have excellent experimental skills. Good communication skills (both presentation and writing skills in English) are also essential. This project is funded by a 4-year BBSRC studentship and applicants should ensure they have understood the funding eligibility criteria for these studentships. Unfortunately, international students are not eligible for programme funding on this project. Applicants should go to http://lido-dtp.ac.uk/lido-apply.html for further information on the LIDo programme and how to apply- the closing date is 24th January at 4 pm. For more information regarding the project, please contact Professor Helen Hailes.

1. H. Schonherr, et al., Angew. Chem. Int. Ed. 2013, 52, 12256.

2. M. R. Bennett, et al., Curr. Op. Chem Biol., 2017, 37, 97.

3. J. Siegrist, et al., FEBS Lett., 2017, 591, 312.

4. S. Mordhorst, et al., Angew. Chem. Int. Ed., 2017, 56, 1.

5. Y. Wang, et al., Angew. Chem. Int. Ed., 2019, 58, 101206.

6. L. Leipold, et al., Green Chem., 2019, 21, 75.

7. R. Roddan, et al., ACS Catal., 2019, 9. 9460.

A three-year PhD studentship in Supramolecular Approaches to Drug Design and Delivery (D/L:28/02/20)

Supervisor: Dr Cally Haynes
Application deadline: 28th February 2020
Start date: 23rd September 2020

UCL Chemistry Department is offering a fully funded studentship to a highly motivated candidate to start in September 2020.The student will carry out their doctoral research at UCL.

 

Project description

We are interested in the application of supramolecular chemistry to medicinal and biological fields. By controlling how a molecule interacts with its surroundings, we can translate existing chemical knowledge into new environments and access novel functions. For more information about the research interests of Dr Cally Haynes, please refer to: https://iris.ucl.ac.uk/iris/browse/profile?upi=CJEHA37.

This project will aim to engineer specific non-covalent interactions (such as hydrogen bonding, halogen bonding and chalcogen bonding) that can reversibly and controllably dictate the interactions of small molecules with their surroundings. We will apply this knowledge to gain control of the cellular uptake and biodistribution of small, functional molecules in order to design new therapeutics and diagnostics that need to be delivered to a particular site in order to function. We will also incorporate our new molecular designs into the controlled construction of functional amphiphiles to mediate specific processes at self-assembled interfaces.

This multidisciplinary project will provide opportunities to work at the interface of chemistry with biological and materials sciences and to collaborate with other researchers in these areas at UCL and further afield. The project will use techniques including advanced NMR and fluorescence spectroscopies, X-ray crystallography and the preparation and handling of model lipid bilayer systems.

The applicants should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in chemistry or a related subject. UK/EU students are eligible for this studentship, which will cover tuition fees at UK/EU rate plus a stipend (tax-free) for three years. We also welcome applications from self-funded students, or those who have alternative funding available.

The successful candidate should be able to work independently and have good communication skills. Curiosity and creativity are highly valued and underpin much of what we do. Prior experience in supramolecular chemistry, organic synthesis and/ or NMR analysis would be an advantage.

Interested candidates should initially contact supervisor Dr Cally Haynes (cally.haynes@ucl.ac.uk) with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged. Suitable candidates will be required to complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply. Any admissions queries should be directed to Dr Jadranka Butorac (j.butorac@ucl.ac.uk).

Applications will be accepted until 28th February 2020 but the position will be filled as soon as a suitable candidate has been identified.

 

A 3-year PhD studentship in self-standing Cathodes for high-performance Zn-ion batteries (D/L:20/07/20)

Supervisors: Prof Ivan Parkin and Dr Yang Xu (UCL), Dr  Sing Yang  Chiam (IMRE, A*STAR, Singapore)
Application deadline: 20 July 2020
Start Date: 28 September 2020
Location: London (1.5 years), Singapore (2 years)

The Studentship

This position is fully funded by the UCL-A*STAR Collaborative Programme via the Centre for Doctoral Training in Molecular Modelling and Materials Science (M3S CDT) at UCL. The student will be registered for a PhD at UCL where he/she will spend year 1 and the first six months of year 4. The second and third years of the PhD will be spent at the A*STAR Institute of Materials Research and Engineering in Singapore. The Studentship will cover tuition fees at UK/EU rate plus a maintenance stipend about £17000 (tax free) pro rata in years 1 and 4. During years 2 and 3, the student will receive a full stipend directly from A*STAR. In addition, A*STAR will provide the student with one-off relocation allowance. Please note that, due to funding restrictions, only UK/EU citizens are eligible for this studentship.

The Project

The aim of this project is to initiate the studies of the physical and chemical properties of inorganic self-standing (manganese, vanadium-based nanostructures) electrodes will be thoroughly investigated.

More specifically, to develop the different types of self-standing electrode through both wet chemistry and thin film fabrication techniques so that the materials can be adopted in industrial applications The evaluation of the electrochemical properties of the electrodes, and the fabrication of coin cells and pouch cells configuration will be realized. The structure-performance relationship will be uncovered through combined ex-situ and in-situ studies. The optimized electrodes can benchmark the best reported capacity electrodes from the literature, also exhibit high performance.

The Candidate

The successful applicant should have or expect to achieve at least a 2.1 honours or equivalent for undergraduate degree in Physics, Chemistry, Materials Science. The successful applicant will demonstrate strong interest and self-motivation in the subject, good experimental practice and the ability to think analytically and creatively. Good computer skills, plus good presentation and writing skills in English, are required. Previous research experience in contributing to a collaborative interdisciplinary research environment is highly desirable but not necessary as training will be provided.

Please contact Prof Parkin (i.parkin@ucl.ac.uk) for further details or to express an interest.

Applications will be accepted until 20 July 2020 but the position will be filled as soon as an appropriate candidate is found.

A 3-year PhD studentship in electronic and mechanical response at 2D buried interfaces (D/L:20/07/20)

Supervisors: Prof G. Thornton (UCL), Dr  S.J. O Shea (IMRE, A*STAR, Singapore)

Application deadline: 20 July 2020

Start Date: 28 September 2020

Location: London (1.5 years), Singapore (2 years)

Topics: scanning probe microscopy, electronic devices, 2D materials

The Studentship

This position is fully funded by the UCL-A*STAR Collaborative Programme via the Centre for Doctoral Training in Molecular Modelling and Materials Science (M3S CDT) at UCL. The student will be registered for a PhD at UCL where he/she will spend year 1 and the first six months of year 4. The second and third years of the PhD will be spent at the A*STAR Institute of Materials Research and Engineering in Singapore. The Studentship will cover tuition fees at UK/EU rate plus a maintenance stipend about £17000 (tax free) pro rata in years 1 and 4. During years 2 and 3, the student will receive a full stipend directly from A*STAR. In addition, A*STAR will provide the student with one-off relocation allowance. Please note that, due to funding restrictions, only UK/EU citizens are eligible for this studentship.

The Project (no more than 150 words, please)

The physical contact between two surfaces is critical for many applications, such as the integrity of electrical connection, the sliding and adhesion of surfaces, the formation of charge barriers for electronic devices, and surface roughness effects in heat transfer and electrical transport.  The aim of the PhD project is to investigate the contact between free standing 2D layers placed on a substrate at the atomic-to-nanoscale using scanning tunneling microscopy (STM) and atomic force microscopy (AFM) in ultrahigh vacuum (UHV) conditions, and relate the measurements to macroscopic effects. We will focus on two types of 2D layers, namely bi-layer SiO2 and hexagonal boron nitride (h-BN). The contact area and number of asperities touching at the plate-substrate interface will change as we apply pressure with the AFM/STM tip. These mechanical changes will also modify the current flow. From such data we can model the change in contact from the nanometre scale to the mesoscale.

The Candidate

The successful applicant should have or expect to achieve at least a 2.1 honours or equivalent for undergraduate degree in Physics, Chemistry, Materials Science. The successful applicant will demonstrate strong interest and self-motivation in the subject, good experimental practice and the ability to think analytically and creatively. Good computer skills, plus good presentation and writing skills in English, are required. Previous research experience in contributing to a collaborative interdisciplinary research environment is highly desirable but not necessary as training will be provided.

Please contact Prof Thornton (g.thornton@ucl.ac.uk) or Dr O Shea (s-oshea@imre.a-star.edu.sg) for further details or to express an interest.

Applications will be accepted until 20 July 2020 but the position will be filled as soon as an appropriate candidate is found.

 

A 3-year PhD studentship in deep-learning assisted design of active hyperuniform materials (D/L:20/07/20)

Supervisors: Dr Giorgio Volpe (UCL), Dr Yuan Cheng (IHPC, A*STAR, Singapore)

Application deadline: 20 July 2020

Start Date: 28 September 2020

Location: London (1.5 years), Singapore (2 years)

Topics: deep learning, soft matter, active matter, photonics, self-assembly, computational sciences

The Studentship

This position is fully funded by the UCL-A*STAR Collaborative Programme via the Centre for Doctoral Training in Molecular Modelling and Materials Science (M3S CDT) at UCL. The student will be registered for a PhD at UCL where he/she will spend year 1 and the first six months of year 4. The second and third years of the PhD will be spent at the A*STAR Institute of High Performance Computing in Singapore. The Studentship will cover tuition fees at UK/EU rate plus a maintenance stipend about £17000 (tax free) pro rata in years 1 and 4. During years 2 and 3, the student will receive a full stipend directly from A*STAR. In addition, A*STAR will provide the student with one-off relocation allowance. Please note that, due to funding restrictions, only UK/EU citizens are eligible for this studentship.

The Project

Hyperuniform materials are a novel class of disordered materials with properties of both liquids and solids. Because of this dual nature, such materials are increasingly interesting for photonics as they can influence the path of light with the efficiency of a crystal while retaining the flexibility of a liquid. The aim of this collaborative project is to develop an efficient computational framework to design optimal hyperuniform materials whose structure can be rearranged dynamically into different configurations capable of unique interaction with light. In particular, this project will develop a new efficient numerical scheme based on the power of deep-learning approaches with neural networks to realize efficient modeling and design of active hyperuniform materials. If properly designed, this level of tunability is promising to realize novel robust functional materials for photonics and beyond.

The Candidate

The successful applicant should have or expect to achieve at least a 2.1 honours or equivalent for undergraduate degree in Chemistry, Physics, Materials Science, Engineering or a related discipline. The successful applicant will demonstrate strong interest and self-motivation in the subject, excellent programming skills (in C++, Matlab, Python or equivalent) and the ability to think analytically and creatively. Good computer skills, plus good presentation and writing skills in English, are required. Previous research experience in contributing to a collaborative interdisciplinary research environment is highly desirable but not necessary as training will be provided.

Please contact Dr Giorgio Volpe (g.volpe@ucl.ac.uk) or Dr Yuan Cheng (chengy@ihpc.a-star.edu.sg) for further details or to express an interest.

Applications will be accepted until 20 July 2020 but the position will be filled as soon as an appropriate candidate is found.

 

Best student PhD studentship 2020 (D/L:24/01/20)

The Department of Chemistry each year has an allocation of funding for PhD studentships. This year we have decided to make one of these available to the 'best' student (at UCL or elsewhere) wishing to stay here to do a PhD.

This studentship will be competitively awarded to final year students (e.g. Chemistry or Chemistry Natural Scientists) or those with a Degree in Chemistry (or equivalent) on the basis of academic record and an interview, which will cover both the student’s chemical knowledge and the project submitted. You should discuss possible PhD projects with academic staff.

You should submit a 2 page CV and a proposal (1 page maximum + a figure) describing your proposed PhD project after consultation with a potential supervisor/s. These should be submitted to Yael Moscou (y.moscou@ucl.ac.uk) by Friday 24th January 4 pm. Interviews for short-listed applicants will be held in February.

Please note: To be eligible for this award, candidates must either be UK or EU residents who have been living in the UK for 3 years immediately prior to the course commencing (for education purposes tis fine). EU residents who have not been living in the UK are eligible for fee only awards. https://www.epsrc.ac.uk/skills/students/help/eligibility/. [This eligibility should be applied unless permission has been given to use an award flexibly, as part of the https://www.ucl.ac.uk/research/beamsfunding/epsrc-studentships/epsrc-stu... 10% overseas quota].

The PhD studentship stipend will be for a maximum of 4 years and also cover fees, and will start at the end of September 2020.

Please direct any questions to Yael Moscou (y.moscou@ucl.ac.uk) in the first instance.

A 4-year PhD studentship in “A chemist’s approach to solving biological problems” (D/L:31/03/20)

Supervisors: Dr Vijay Chudasama and Dr James Baker
Application deadline:
31st March 2020
Start date: September 2020

UCL Chemistry Department is offering a fully funded studentship to a highly motivated candidate to start in Organic Chemistry and Chemical Biology. An industrial CASE PhD position (over 4 years) is available to work with Dr Vijay Chudasama, Dr James Baker and LifeArc to aid in providing significant steps in this direction via the creation of protein-conjugates generated by site-specific protein modification. The student will carry out his/her doctoral research at UCL and also have the opportunity for work placements at LifeArc. There is a clear need for Organic Chemists to contribute to the field of Biology through the conduit of Chemical Biology. This project will be based on using core synthetic organic chemistry to deliver entities that will meet the needs of forming the next-generation of protein-based therapeutics.

In the area of site-selective protein modification, we are at the centre of developing a ground-breaking technology based on the insertion of small molecules bearing reactive handles into native disulfide bonds and cysteines. Our strategy has been well received in the literature (e.g. Chem. Commun., 2020, DOI: 10.1039/C9CC08744C; Chem. Commun., 2019, 55, 14829; Chem. Sci., 2019, 10, 10919; Nature Chem. Bio., 2018, 14, 955; ACS Nano, 2018, 12, 279; Chem. Sci., 2017, 8, 2056; Nature Chem., 2016, 8, 114; Chem. Sci., 2016, 7, 799; Chem. Sci., 2017, 8, 63; Nature Commun., 2015, 6, 6645; Chem. Commun., 2015, 51, 15304; Chem. Commun., 2015, 51, 10624; full list can be found here: http://chudasama-group.eu/publications/) and we hope to continue to publish greatly in this area. With our experience, interesting challenges in the modification of certain peptides and proteins have arisen. There is an opportunity to contribute to this area and make a significant impact to the field of Chemical Biology.

Studentship_Chudasama_310320

The student will gain valuable research expertise during the course of this project, making them well qualified for future employment in either an academic or industrial setting. This project will provide a thorough training in synthetic organic chemistry and chemical biology, as well as in a series of transferable skills. The student will also be given plenty of opportunity to be creative, and includes a placement at LifeArc.

Qualifications

We are looking to recruit a highly motivated and ambitious organic chemist with an excellent background in synthetic organic chemistry and an interest in chemical biology. Experience in chemical biology is not a pre-requisite as this project has synthetic organic chemistry at its core and extensive training in chemical biology will be provided. The project will involve various spectroscopic and analytical techniques such as NMR, MS, IR, LC-MS, SDS-PAGE and MALDI-TOF; thus proving the student with an excellent training in a variety of techniques.

Application Details

The applicants should have, or be expecting to achieve, a first or upper second class Honours degree in Chemistry or equivalent. Due to funding restrictions, this studentship is only open to applicants from the UK and EU, who have been resident in the UK for at least 3 years preceding their start on the programme or have indefinite leave to remain in the UK. Interested candidates should initially contact supervisor Dr Vijay Chudasama with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged.  Suitable candidates will be required to complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply. Any admissions queries should be directed to Dr Jadranka Butorac (j.butorac@ucl.ac.uk). 

Applications will be accepted until 31st March 2020 but the position will be filled as soon as a suitable candidate has been identified.

 

A 3-year PhD studentship in Metal Oxide Thin Films for Electronic Devices (D/L:30/04/20)

Supervisor: DI Dr Anna Regoutz
Application deadline: 30th April 2020
Start date: 28th September 2020

UCL Chemistry Department is offering a fully funded studentship to a highly motivated candidate to start in September 2020.


Metal oxides are one of the top candidates to help us move from the silicon age into a new era of more powerful, energy efficient, and flexible electronics. They show the widest range of physical characteristics of any material family and in devices are often used in the form of thin films. High-quality oxide films are necessary to develop advanced device generations and in this project you will explore wet chemistry processes, like sol-gel synthesis, to prepare such films.[1-3] The sol-gel process is fast, inexpensive, technologically simple, and can be executed at low temperatures enabling the use of flexible substrates. Through adjustment of the process parameters, including precursor type and concentration, use of stabilisers and catalysts, reaction temperature, and many more, the film characteristics can be engineered and optimised. This approach allows the comparatively easy fabrication of high-quality new oxide thin film materials, which can subsequently be tested for their fundamental chemical and physical characteristics. You will investigate structure, electronic structure, and chemical state of the thin films using a combination of characterisation techniques including X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Scanning Electron Microscopy (SEM) and atomic force microscopy (AFM). The detailed knowledge of the characteristics and behaviour of new materials then enables their implementation in applications, such as new generations of electronic and optical devices. This project will combine elements of thin film deposition, solid state chemistry, and electronic devices. It is best suited for students with a keen interest in multidisciplinary work at the interface of fundamental materials chemistry and device applications. The project is hosted in the group of DI Dr Anna Regoutz and more information on the group’s work can be found at https://a-x-s.org/.
 

The applicants should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in Chemistry, Physics, Materials Science or a related subject. Due to funding restrictions, this studentship is only open to applicants from the UK and EU.

Interested candidates should initially contact the supervisor DI Dr Anna Regoutz (a.regoutz@ucl.ac.uk) with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged.  Suitable candidates will be required to complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply. Any admissions queries should be directed to Dr Jadranka Butorac (j.butorac@ucl.ac.uk).


Applications will be accepted until 30th April 2020 but the position will be filled as soon as a suitable candidate has been identified.

Funded 3-year PhD studentship in ultrafast optical and X-ray spectroscopy (D/L:30/04/20)

Supervisor: Rebecca A. Ingle
Start date: October 2020

 

A fully funded PhD studentship is now available to work in the group of Dr Rebecca Ingle at UCL Chemistry on using optical and X-ray spectroscopies to explore photoinduced processes in the gas phase and solution of biologically and technologically relevant molecules.

The successful candidate will have the chance to partake in the development of new UCL Laser Facility as well as develop experiments at international X-ray synchrotron and free electron laser facilities. Enthusiasm and willingness to learn is more essential than prior experience of the techniques involved.

The applicants should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in Chemistry, Physics or a related degree. Due to funding restrictions, this studentship is only open to applicants from the UK and EU, who have been resident in the UK for at least 3 years preceding their start on the programme or have indefinite leave to remain in the UK.

Interested candidates should initially contact supervisor Rebecca Ingle (r.ingle@ucl.ac.uk) with a motivation letter expressing their interest in the project and CV with expected/anticipated degree mark. Informal inquiries are encouraged.  Suitable candidates will be required to complete an electronic application form at http://www.ucl.ac.uk/prospective-students/graduate/apply. Any admissions queries should be directed to Dr Jadranka Butorac (j.butorac@ucl.ac.uk).

Early application is encouraged as the position will be filled as soon as a suitable candidate has been identified.