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Dr Kersti Karu

Manager of Mass Spectrometry Facility 

Taking full responsibility for the day to day operational management of UCL Chemistry Mass Spectrometry Facility with a focus on research projects from UCL and other universities also routine LC-MS, MS/MS, GC-MS, accurate mass measurements analyses. The laboratory is equipped with a sector MAT900 instrument, LCT Premier Q-TOF mass spectrometer, Agilent LC 6510 Q-TOF mass spectrometer, Thermo GC-MS with a static headspace and liquid injection autosampler, Thermo capLC with LTQ mass spectrometer, Waters micro MALDI mass spectrometer and Waters UPLC with SQD detector. 

Publications

  1. Veeravalli, S., Karu, K., & Shephard, E. A. (n.d.). Capillary liquid chromatography mass spectrometry analysis of trimethylamine and trimethylamine N-oxide and creatinine in mouse urine.
  2. Aliev, A. E., Karu, K., Mitchell, R. E., & Porter, M. J. (2016). The structure of tagetitoxin. Organic & biomolecular chemistry, 14 (1), 238-245.
  3. Patel, A. V., Blunden, G., Cary, P. D., Opletal, L., Berankova, M., Karu, K., . . . Pour, M. (2008). T-cadinol nerolidol ether from Schisandra chinensis. Natural Product Communications, 3, 1453-1456.
  4. Wang, Y., Karu, K., & Griffiths, W. J. (2007). Analysis of neurosterols and neurosteroids by mass spectrometry. Biochimie, 89 (2), 182-191. doi:10.1016/j.biochi.2006.10.008
  5. Gaitzsch, J., Karu, K., & Battaglia, G. (2015). Peptoidosomes as nanoparticles from amphiphilic block alpha-peptoids using solid-phase-synthesis. European Polymer Journal, 73, 447-454. doi:10.1016/j.eurpolymj.2015.10.026
  6. Karu, K., Hornshaw, M., Woffendin, G., Bodin, K., Hamberg, M., Alvelius, G., . . . Griffiths, W. J. (2007). Liquid chromatography-mass spectrometry utilising multi-stage fragmentation for the identification of oxysterols. Journal of Lipid Research, 48, 976-987. doi:10.1194/jlr.M600497-JLR200
  7. Karu, K., Turton, J. A., Wang, Y., & Griffiths, W. J. (2011). Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation. Chemistry and Physics of Lipids. doi:10.1016/j.chemphyslip.2011.04.011
  8. Ashiru, D. A., Karu, K., Zloh, M., Patel, R., & Basit, A. W. (2011). Relative quantification of polyethylene glycol 400 excreted in the urine of male and female volunteers by direct injection electrospray-selected ion monitoring mass spectrometry. Int J Pharm, 414 (1-2), 35-41. doi:10.1016/j.ijpharm.2011.04.061
  9. Ali, F., Zakkar, M., Karu, K., Lidington, E. A., Hamdulay, S. S., Boyle, J. J., . . . Mason, J. C. (2009). Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow. J Biol Chem, 284 (28), 18882-18892. doi:10.1074/jbc.M109.009886