Chemistry for Life Research Theme Seminar

27 October 2022, 1:00 pm–2:00 pm

UCL Campus image

Platforms for the intracellular generation and high-throughput screening of cyclic peptide libraries

Event Information

Open to

UCL staff | UCL students




Stefan Howorka


Ramsay Lecture Theatre
Christopher Ingold Building
20 Gordon St
N15 3TB
United Kingdom

Cyclic peptide libraries hold significant potential when deployed against challenging targets, such as protein-protein interactions. SICLOPPS is a genetically encoded platform for the rapid intracellular generation of cyclic peptide libraries of over a hundred million members. SICLOIPPS libraries can be generated in a variety of organisms (in E. coli, yeast or mammalian cells) and interfaced with a number of high-throughput assays. We have also developed a microfluidics based platform for the generation and screening of SICLOPPS libraries in fL droplets. The use of the above approach for the identification of inhibitors of a variety of challenging targets will be discussed, including several first in class compounds. We will also discuss examples of taking the cyclic peptides hits form the above screen forward, beyond hits towards the clinic.

Prof. Tavassoli will be available for personal meetings (onsite at UCL Chemistry or online) on 27 October. Please contact s.howorka@ucl.ac.uk if you want meet the speaker.

The seminar will also be streamed: Zoom Details  https://ucl.zoom.us/j/92656660726?pwd=VUlzTlltWFdDZEpWUjZJNE84S3RUUT09  Meeting ID: 926 5666 0726  Password 005935  

About the Speaker

Dr Ali Tavassoli

at University of Southampton