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Chemical Sustainability Research Theme Seminar
17 November 2021, 1:00 pm–2:00 pm
Synthetic Enzyme Cascades – from Set-Up to Optimisation Prof Dörte Rother, Jülich GmbH and RWTH Aachen University
Event Information
Open to
- UCL staff | UCL students
Availability
- Yes
Organiser
-
Prof. Helen Hailes
Location
-
VirtualChristopher Ingold Building, UCLLondonWC1H 0AJUnited Kingdom
Enzymatic multi-step reactions offer significant potential to yield fine-chemicals and active pharmaceutical ingredients (API) with excellent stereoselectivities. But the access to economically feasible product concentrations can be a challenge. This challenge can be met using an integrated engineering approach that includes enzyme engineering, reaction optimisation and optimal process design. Examples of modular synthetic enzyme cascades for the production of active substances with selectivities >98 % and product concentrations >50 g/L are presented. Unconventional reaction media are also considered to achieve high product titres and facilitate product purification.
