Queen Square Centre for Neuromuscular Diseases


A study using Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) in patients with Limb girdle muscular dystrophy 2I (LGMD2I) ; an assessment of skeletal and cardiac muscle damage

Sponsor / Funder Newcastle upon Tyne NHS Hospitals Foundation Trust
CI Professor Volker Straub
Sites Newcastle, London Queen Square
Contact details j.morrow@ucl.ac.uk

We intend to rescan and assess the original 2009-2010 cohort of LGMD2I patients with both functional and imaging measures.

Primary objective

To evaluate the non-invasive measurements of fat fraction to quantify muscle pathology.

Secondary objective

To evaluate the rate of change of muscle fat replacement over five years.

This will be achieved by measuring morphology by MRI and comparing the results to the original study from 5 years ago. We will at the same time assess heart function with MRI.