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Queen Square Centre for Neuromuscular Diseases

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Cardiac adaptation to exercise in Mitochondrial disease

Sponsor Newcastle upon Tyne Hospitals NHS Foundation Trust
Funder MRC
CI Professor Turnbull
Sites Newcastle
Contact details Julia.maddison@newcastle.ac.uk
More information

Recruitment

24 people with mitochondrial disease will take part in the study. Participants, aged 18−60 years, will have biopsy proven mitochondrial disease.

Study information

Participants will undergo heart, cognitive and movement examination at baseline and at 16 weeks. An exercise test will be undertaken at baseline to determine maximal aerobic capacity and check for an adverse response to exercise. They will then be randomised into two groups to receive, over a 16 week period, either:

  • exercise counselling and support (n = 12)
  • or continue standard care (n = 12)

The patient exercise group will be matched with a control group of individuals with no mitochondrial disease. They will undergo the same evaluation and training regime (n = 12).

Participants will need to attend the research facility for three visits for assessments. The exercise groups will be requested to attend 48 exercise sessions over 16 weeks.