Queen Square Centre for Neuromuscular Diseases


Diagnosis and treatment


The following treatment is available:

  • Pyridostigmine and immunosuppressant drugs
  • Intravenous immunoglobulin and plasma exchange therapy (severe or rapidly worsening Myasthenia) 
  • Thymectomy (offered at another hospital)

Our treatment choices are informed by clinical trial evidence (not available for thymectomy).

Other conditions

For patients with LEMS and congenital myasthenic syndromes, we may use 3,4 diaminopyridine and other agents that act on the neuromuscular junction.


Some patients with myasthenic syndromes can develop diaphragmatic weakness (the diaphragm is the main muscle to help breathing). This can lead to breathing difficulties and particularly affects patients during sleep.

We have a specialist service run by one of our neuroanaesthetists and a clinical nurse specialist (Helen Eddleston).

They provide a home sleep study diagnostic service and can provide treatment in the form of non-invasive ventilation.

Patient advice

Our clinical nurse specialist provides advice via telephone and email as well as an immunosuppression monitoring service.

The service works closely with the sleep service (non-invasive ventilation), Dr. Gordon Plant (neuro-ophthalmology) and therapy services (Speech and Language, Physiotherapy).

We provide a service for patients throughout Greater London and the surrounding areas. We also see patients both nationally and internationally.