- About us
- Our Research
- Funding Opportunities
- Help for Parents
- Job Vacancies
- News / Press & Media
- Contact us
Special Podcast Dev Cog Neuro Journal: June 2013
Latest Quarterly Journal of:
(Volume 7: January 2014)
2012 Impact Factor: 3.160
Functional and Structural Brain Imaging to guide Neurosurgical Treatment of Epilepsy: A Systematic Pre- to Post-operative Evaluation in Children
Great Ormond Street Hospital (GOSH) is a leading centre for epilepsy treatment, carrying out over 70% of epilepsy surgery in children in the UK since 1992. Surgical intervention for epilepsy is an effective treatment in individuals who show poor response to anti-epileptic medications and in whom seizure onset can be localised to one area of the brain. Before surgery is carried out, it is important to map out essential functions in the brain, to determine whether the area of the brain responsible for seizures can be accurately defined and that removal of the area is not going to compromise important functions, for example in the control of movement, memory, or language. Functional MRI (fMRI) investigations of language are now routinely performed on most children undergoing presurgical evaluations at GOSH. However, outcome after resections in regions of the brain underpinning language has not been well documented.
We are carrying out a comprehensive follow-up investigation of children with epilepsy surgery, with the aim to identify factors which promote positive cognitive outcome and recovery. These children underwent extensive neuropsychological and neuroimaging investigations as a part of investigations for epilepsy surgery (including language mapping by fMRI, and neuropsychological evaluations of language, intellectual abilities and memory). Specifically, we will be investigating the effect of surgical resection in proximity to language areas in the brain, alongside structural brain indices (the integrity of white matter tracts, using Diffusion Weighted Imaging (DWI) and developmental changes in and grey matter volume). We will use functional and structural neuroimaging (performed pre- and post-operatively) to establish if reorganisation of brain functions after surgery combined with improved seizure status after surgery result in a favourable long-term outcome. We aim to identify markers of brain function and structure that are associated with positive outcome, which we hope will help to further improve treatment and inform patients and families of expected risks and benefits of surgery.
studies of children with surgical intervention for epilepsy require adequate
comparison groups, ideally a non-surgical comparison group with similar seizure
profiles, and a healthy control comparison. This helps to us to understand whether outcome in children with epilepsy
surgery is associated with surgery or with intractable seizures.
We are currently looking for healthy children, adolescents and young adults who would be interested taking part in this study. This would involve attending a research appointment at the Institute of Child Health and undergoing a brain scan at GOSH. If you are interested in participating or would like more information, please email us on:
Rosie Coleman - firstname.lastname@example.org
Caroline Skirrow - email@example.com or
Torsten Baldeweg - firstname.lastname@example.org