First Year CDB PhD Students: Mini Symposium
Tuesday 1 July, 1.30-4.10pm
Host: Yoshiyuki Yamamoto
1.45pm Francis Carpenter: “Neural Representations of Space in Connected, Perceptually Identical Compartments”
2.00pm Chris Penny: "The functional architecture of Two-Pore Channels"
2.15pm Amina Yonis: “The role of actin nucleators in the cellular actin cortex”
2.30pm Lewis Brayshaw: ”Cadherin de-adhesion in cancer”
2.45pm Agnieszka Piatkowska: “Mechanism of somite formation”
3.10pm Alan Greig: “Pertussis vaccination and dysfunction of the blood brain barrier: an in vitro study”
3.25pm Marina Teter: “The role of Wnt antagonists in synapse vulnerability”
3.40pm Gauri Bhosale: “Investigating the mitochondrial permeability transition pore as a therapeutic target in human disease”
3.55pm Lourdes Sri Raja: "Modelling Protein Signalling Pathways during Neutrophil Differentiation"
Thursday July 3rd, 12pm
Dr Yoshiyuki Yamamoto
Research in our lab focuses on understanding the molecular mechanisms underlying the generation of morphological novelties during evolution. We are using the Mexican tetra Astyanax mexicanus as a model system for studying evolution, development and regeneration.
Evolution, development and regeneration
Astyanax mexicanus exhibits both eyed surface (surface fish: Figure 1) and eyeless cave (cavefish: figure 2) populations. During the late Pleistocene (about 10,000 to 100,000 years ago), the surface fish diverged into at least 30 distinct cavefish populations in northern Mexico. Since then, the cavefish have evolved regressive characters such as degenerate eyes, a smaller optic tectum, and less pigment, but they also have evolved constructive characteristics such as a larger jaw and additional teeth, cranial neuromasts, and taste buds. We use molecular and experimental embryological techniques to study the mechanisms by which this evolution occurred. Our research mainly focuses on the following projects:
· Mechanisms and evolutionary forces of cavefish eye degeneration
· Brain evolution
· Craniofacial development and evolution
· Heart development and regeneration
If you are interested in participating in these research projects, feel free to contact us, e-mail: firstname.lastname@example.org
· Yoshiyuki Yamamoto E-mail: email@example.com
· Mathilda Mommersteeg (Postdoctoral Research Fellow): firstname.lastname@example.org
· Fábio Rodrigues (Student)
· Amy Munro-Faure (Student)
· Jake Wyatt (Student)
Department of Cell and Developmental Biology
University College London
London WC1E 6BT
Publications and further information
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