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CDB Seminars
All welcome

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All Seminars are held in the Gavin De Beer Lecture Theatre, Anatomy Building, Thursday 1-2pm (unless otherwise stated)

Thursday 9 July: midday-2.40pm

Host: Yoshiyuki Yamamoto

Room 249, 2nd Floor, Medical Sciences Building, Gower Street

12.00pm  Heather Steele-Stallard: “Human iPS cell-based platforms for disease modelling and therapy screening for laminopathies”
12.15pm  Terry Felton: “Regulation of asymmetric neurogenesis in C. elegans
12.30pm  Marcus Ghosh: “Assigning Behavioural and Neurodevelopmental Functions to Autism-associated Genes”
12.45pm  Giulia Ferrari: “Towards a genomic integration-free, iPS cell and human artificial chromosome-based therapy for Duchenne muscular dystrophy”
1.00pm  Michele Sammut: “Mystery cells in C.elegans: Sex, Glia transdifferation and Learning”
1.15pm  Johanna Buchler: "The Wnt co-receptor LRP6 and synapse regulation".
1.30pm  

Interval
1.40pm  Renato Martinho: “The Asymmetric Habenula of Zebrafish: from Transcriptome to Behaviour”
1.55pm  Alex Fedorec: “Plasmid persistence: balancing plasmid stability and host competitiveness”
2.10pm  Maryam Khosravi: "Investigating novel genetic associations with ciliopathy in the zebrafish"
2.25pm  Marc Williams: “Identification of neutral tumour evolution across cancer types”

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Professor Stephen Davies

Prof Steve Davies


Stephen Davies is Professor of Molecular Neuropathology

s.w.davies@ucl.ac.uk

Telephone:

Office - 020 7679 2677
(Int: 32677)

Lab - 020 7679 2126
(Int: 32126)

View Prof Davies' Lab Research website here and his Profile on the School of Life and Medical Sciences here

Research Interests

The ultrastructural and molecular organisation of the neuronal nucleus.

Research Description

The neuronal cell nucleus has a characteristic and highly specialised organisation. The nucleolus appears to act as a central organising region around which there is a complex organisation of subnuclear structures, such as the perinucleolar rosette and a large perinucleolar cap of heterochromatin. We are currently defining the molecular and ultrastructural composition of these domains. The rosette is made up of 1-2 domains containing the Cajal Body protein p80 coilin together with Nopp140 and the SMN complex, the remainder contain Nopp140. The heterochromatin caps contain large areas of MeCP2 and are associated with smaller domains containing the chromosome centromeres or the polycomb protein complex. All these areas are variably marked by trimethylated histones. We are further defining this complex organisation by comparing it with 1) the spatial patterns of gene expression occurring in neurons in vivo and 2) the 3d spatial arrangement of genes within the nucleus of defined neurons Why do we think that this complex arrangement of neuronal nuclear structure is of importance for human neurological disease? We have shown that in Huntington's disease the neuronal nucleus reorganises to accommodate a large intranuclear inclusion such that the perinucleolar rosette is disrupted to allow movement of the Cajal body like p80 coilin positve structure to attach to the newly formed inclusion. This results in a profound rearrangement of the nucleolar structure, dissociation away from defined chromosomal domains and transcriptional dysregulation. Similar disruption of these structures occurs in spinal muscular atrophy (SMA), fragile X tremor ataxia syndrome (FXTAS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD). We are currently investigating the functional consequences of nuclear disruption in these conditions.

IRIS

Page last modified on 26 sep 14 12:29 by Edward D Whitfield