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CDB Seminars
All welcome

Thursday April 24th, 1pm
Prof Justin Blau, NYU
Title: How flies time: Neurobiology of the Drosophila circadian clock
Host: Prof Ralf Stanewsky
Venue: Anatomy G04 Gavin de Beer LT

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Friday April 25th, 1pm
Dr Benedetta Ruzzenente, Max Planck Institute
Title: RNA Metabolism in Mitochondria: Lessons from the Mouse
Host: Prof Michael Duchen
Venue: Medawar G02 Watson LT

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Thursday May 1st, 1pm
Dr Setsuko Sahara, MRC - Kings
Title: Control of cortical neuron number
Host: Prof John Parnevelas
Venue: Anatomy G04 Gavin de Beer LT

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Thursday May 8th, 1pm
Prof Robert Lightowlers, Newcastle University
Title: Mitochondrial gene expression in humans: a tale of two tales
Host: Dr Gyorgy Szabadkai
Venue: Medical Sciences 131 A V Hill LT

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Professor Stephen Davies

Prof Steve Davies


Stephen Davies is Professor of Molecular Neuropathology

s.w.davies@ucl.ac.uk

Telephone:

Office - 020 7679 2677
(Int: 32677)

Lab - 020 7679 2126
(Int: 32126)

View Prof Davies' Lab Research website here and his Profile on the School of Life and Medical Sciences here

Research Interests

The ultrastructural and molecular organisation of the neuronal nucleus.

Research Description

The neuronal cell nucleus has a characteristic and highly specialised organisation. The nucleolus appears to act as a central organising region around which there is a complex organisation of subnuclear structures, such as the perinucleolar rosette and a large perinucleolar cap of heterochromatin. We are currently defining the molecular and ultrastructural composition of these domains. The rosette is made up of 1-2 domains containing the Cajal Body protein p80 coilin together with Nopp140 and the SMN complex, the remainder contain Nopp140. The heterochromatin caps contain large areas of MeCP2 and are associated with smaller domains containing the chromosome centromeres or the polycomb protein complex. All these areas are variably marked by trimethylated histones. We are further defining this complex organisation by comparing it with 1) the spatial patterns of gene expression occurring in neurons in vivo and 2) the 3d spatial arrangement of genes within the nucleus of defined neurons Why do we think that this complex arrangement of neuronal nuclear structure is of importance for human neurological disease? We have shown that in Huntington's disease the neuronal nucleus reorganises to accommodate a large intranuclear inclusion such that the perinucleolar rosette is disrupted to allow movement of the Cajal body like p80 coilin positve structure to attach to the newly formed inclusion. This results in a profound rearrangement of the nucleolar structure, dissociation away from defined chromosomal domains and transcriptional dysregulation. Similar disruption of these structures occurs in spinal muscular atrophy (SMA), fragile X tremor ataxia syndrome (FXTAS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD). We are currently investigating the functional consequences of nuclear disruption in these conditions.

Page last modified on 25 may 10 14:50 by Glenda Young