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UCL Institute of Cardiovascular Science

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Dark Space Project (DSP)

The Dark Space Project is an initiative lead by the IntAct database to capture interaction information that is reported in the literature but is not represented in IMEx databases.

We are contributing to this project by prioritising the curation of a list of human genes known to be related to cardiac risk, and which we extracted from this publication: Global Lipids Genetics Consortium et al., 'Discovery and refinement of loci associated with lipid levels', Nat. Genet., vol. 45, no. 11, pp. 1274-1283, Nov. 2013 (PMID 24097068).

Our priority list contains genes that do not have any interaction data in IMEx databases or in the EBI-GOA-nonIntAct dataset. The latter is curated to the GO (Gene Ontology) standard i.e. not to the deep curation level of IMEx rules.

Here is the list of priority genes:

 HGNC Gene NameHGNC Gene Symbol
1ATP-binding cassette sub-family A member 8ABCA8
2Cartilage intermediate layer protein 2CILP2
3Cytochrome P450 family 26 subfamily A member 1CYP26A1
4Cytochrome P450 family 7 subfamily A member 1CYP7A1
5Dynein axonemal heavy chain 11DNAH11
6Fatty acid desaturase 3FADS3
7Krueppel-like factor 14KLF14
8Solute carrier family 39 member 8SLC39A8
9ST3 beta-galactoside alpha-2,3-sialyltransferase 4ST3GAL4
10T-cell immunoglobulin and mucin domain-containing protein 4TIMD4
11Aldo-keto reductase family 1 member C4AKR1C4
12Angiopoietin like 1ANGPTL1
13G protein-coupled receptor 146GPR146
14Potassium two pore domain channel subfamily K member 17KCNK17
15Olfactory receptor family 4 subfamily C member 46OR4C46
16Monoacylglycerol O-acyltransferase 2MOGAT2
17Phosphatidylinositol glycan anchor biosynthesis class VPIGV
18Hydroxycarboxylic acid receptor 2HCAR2
19Ribosomal RNA adenine dimethylase domain containing 1RRNAD1
20Zinc finger DHHC-type containing 18ZDHHC18