Lead: Dr Vivek Muthurangu
Location: Level 1, Variety Club Builiding, Centre for Cardiovascular Imaging, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH
Overview: We are a multi-disciplinary group of MR physicists, computer scientists, radiographers and clinicians involved in developing and validating novel methods of imaging the cardiovascular system. We are based at both Great Ormond Street and the Royal Free hospitals and with research spanning all age ranges. Our technical research is mainly related to developing rapid MR sequences based on non-Cartesian trajectories and new image reconstruction methods. We have a particular interest in spiral MRI and parallel imaging/compressed sensing GPU based reconstructions. Our clinical research encompassing validation of new sequences and sophisticated evaluation of cardiovascular physiology. In the past few years we have successfully implemented real-time CMR in infants without anaesthetic and are actively attempting to develop simple 5-minute CMR scans for pediatric heart disease. We also have a keen interest in exercise stress CMR and are active in developing new methodologies and protocols.
1.Knight DS, Steeden JA, Moledina S, Jones A, Coghlan JG, Muthurangu V. Left ventricular diastolic dysfunction in pulmonary hypertension predicts functional capacity and clinical worsening: a tissue phase mapping study. J Cardiovasc Magn Reson. 2015 Dec 29;17:116. doi: 10.1186/s12968-015-0220-3.
2. Taylor AM, Sebire NJ, Ashworth MT, Schievano S, Scott RJ, Wade A, Chitty LS, Robertson N, Thayyil S. Postmortem cardiovascular magnetic resonance imaging in fetuses and children: a masked comparison study with conventional autopsy.
Magnetic Resonance Imaging Autopsy Study Collaborative Group. Circulation
3. Pandya B, Quail MA, Steeden JA, McKee A, Odille F, Taylor AM, Schulze-Neick, Derrick G, Moledina S, Muthurangu V. Real-time magnetic resonance assessment of septal curvature accurately tracks acute hemodynamic changes in pediatric pulmonary hypertension. Circ Cardiovasc Imaging. 2014 Jul;7(4):706-13.
4. Moledina S, Pandya B, Bartsota M, McMillan MR, Mortenson KH, Quyam S, Taylor AM, Haworth SG, Schulze-Neick I, Muthurangu V. Prognostic significance of cardiac magnetic resonance imaging in children with pulmonary hypertension. Circ Cardiovasc Imaging. 2013
5. Steeden JA, Knight D, Bali S, Atkinson D, Taylor AM, Muthurangu V. Self-Navigated Tissue Phase Mapping Using a Golden-Angle Spiral Acquisition – Proof of Concept In Patients With Pulmonary Hypertension. Magn Res Med. 2013 Feb 14
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