UCL Institute of Cardiovascular Science


Centre for Children's Heart Diseases


Lead: Dr Kate Brown

Group Members: Professor Michael Burch, Professor Victor Tsang, Professor Jan Marek, Dr Jo Wray, Dr Alessandro Giardini, Dr Shahin Moledina, Dr Juan Kaski, Dr Troy Dominguez


Location: Level 7, Nurses Home, Cardiac Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH



Great Ormond Street Hospital for Children is one of the leading paediatric cardiac centres in the world, treating children with both congenital and acquired paediatric heart disease. Our vision is that every child with heart disease should have as normal a childhood as possible, and our mission is to improve the quality of life for children with heart disease through translation of new treatments into safe patient care, whilst training the next generation of clinicians and researchers. Our research focuses on translating novel patient-specific treatment options into safe patient care pathways that will be of national and international significance. We have developed many of the tools to achieve this over the last 5 years: phenotyping (imaging, biomarkers), novel treatments (percutaneous pulmonary valve, tracheal transplant, cardiac support devices, stem cells), and computer modelling of cardiovascular disease for patient-specific treatment, combined with meticulous outcomes and quality of life data. This means that we are now in a position to take advantage of our large, unique patient populations in congenital heart disease and cardiomyopathies, and our national patient populations funded through highly specialised services in paediatric transplant, pulmonary hypertension, bridge to transplant, neonatal ECMO, paediatric ECMO and tracheal interventions to test and design novel treatment options and define patient care pathways. Furthermore, systematic collection of both genetic and tissue data will enable us to begin to understand the pathophysiology of the diseases we treat in a way which we have not previously done.

Highlights: Up to 5 key papers and achievements

1. Hsia TY, Figliola R; Modeling of Congenital Hearts Alliance (MOCHA) Investigators.; Modeling of Congenital Hearts Alliance MOCHA Investigators. Multiscale modelling of single-ventricle hearts for clinical decision support: a Leducq Transatlantic Network of Excellence. Eur J Cardiothorac Surg. 2016 Feb;49(2):365-8. doi: 10.1093/ejcts/ezv368

2. Andrews RE, Fenton MJ, Dominguez T, Burch M. Heart failure from heart muscle disease in childhood: a 5-10 year follow-up study in the UK and Ireland. British Congenital Cardiac Association. ESC Heart Fail. 2016 Jun;3(2):107-114.

3. Crowe S, Knowles R, Wray J, Tregay J, Ridout DA, Utley M, Franklin R, Bull CL, Brown KL. Identifying improvements to complex pathways: evidence synthesis and stakeholder engagement in infant congenital heart disease. BMJ Open. 2016 Jun 6;6(6):e010363. doi: 10.1136/bmjopen-2015-010363.

4. Giardini A, Fenton M, Derrick G, Burch M. Impairment of heart rate recovery after peak exercise predicts poor outcome after pediatric heart transplantation. Circulation. 2013 Sep 10;128(11 Suppl 1):S199-204. doi: 10.1161/CIRCULATIONAHA.112.000369.

5. Krupickova S, Muthurangu V, Hughes M, Tann O, Carr M, Christov G, Awat R, Taylor A, Marek J. Echocardiographic arterial measurements in complex congenital diseases before bidirectional Glenn: comparison with cardiovascular magnetic resonance imaging. Eur Heart J Cardiovasc Imaging. 2016 Apr 20. pii: jew069. [Epub ahead of print]

Contact details: Katherine.Brown@gosh.nhs.uk

Website: http://www.gosh.nhs.uk/medical-information-0/clinical-specialties/cardiology-information-parents-and-visitors