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UCL Institute of Cardiovascular Science

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Centre for Outcomes in Paediatric Critical Illness and Cardiovascular Disease

Lead: Dr Katherine (Kate) Brown


Group Members: Professor Jo Wray, Dr Aparna Hoskote, Dr Suzan Kakat, Dr Veena Rajagopal, Professor Victor Tsang
Location: Level 3, Zayed Centre for Rare Diseases

Overview:

We are a multi-disciplinary team within Great Ormond Street Hospital for Children and UCL Institute of Cardiovascular Science in London, with a focus on understanding how childhood critical illnesses and cardiovascular diseases affect a range of outcomes including survival, child development and quality of life. We explore how health services and treatments interact with and influence the outcomes of children's critical illness and heart diseases. We collaborate with a range of other teams within Great Ormond Street Hospital, UCL, Nationally and Internationally. Our research methods include data science, qualitative methods and health care evaluation. 

Recent Highlights:

What was the impact of the first wave of COVID-19 on the delivery of care to children and adults with congenital heart disease? A qualitative study using online forums.

Wray J, Pagel C, Chester AH, Kennedy F, Crowe S. BMJ Open. 2021 Sep 30;11(9):e049006. doi: 10.1136/bmjopen-2021-049006

Supporting families of children with an undiagnosed genetic condition: Using co-design to ensure the right person is in the right post doing the right job.

Oulton K, Gibson F, Williams A, Geoghegan S, Aldiss S, Wray J. Child Care Health Dev. 2021 May;47(3):300-310. doi: 10.1111/cch.12838. Epub 2021 Feb 15

Neurodevelopmental status and follow-up in preschool children with heart disease in London, UK.

Hoskote A, Ridout D, Banks V, Kakat S, Lakhanpaul M, Pagel C, Franklin RC, Witter T, Lakhani R, Tibby SM, Anderson D, Tsang V, Wray J, Brown K. Arch Dis Child. 2021 Mar;106(3):263-271.

Cohort study of intervened functionally univentricular heart in England and Wales (2000-2018).

Hadjicosta E, Franklin R, Seale A, Stumper O, Tsang V, Anderson DR, Pagel C, Crowe S, Espuny Pujol F, Ridout D, Brown KL.  Heart. 2021 Oct 27:heartjnl-2021-319677. doi: 10.1136/heartjnl-2021-319677

What's new in mechanical support strategies for the intensivist in children with severe cardiac failure.

Hoskote A, Stiller B, Thiagarajan RR. Intensive Care Med. 2021 Oct;47(10):1152-1155

Cone reconstruction for Ebstein anomaly: Late biventricular function and possible remodeling.

Neijenhuis RML, Tsang VT, Marek J, Issitt R, Bonello B, Von Klemperer K, Hughes ML. J Thorac Cardiovasc Surg. 2021 Mar;161(3):1097-1108. doi: 10.1016/j.jtcvs.2020.10.124. Epub 2020 Nov 13

Parental understanding of our communication of morbidity associated with paediatric cardiac surgery: a qualitative study.

Rajagopal V, Brown K, Pagel C, Wray J BMJ Paediatr Open. 2020 Feb 26;4(1):e000578. doi: 10.1136/bmjpo-2019-000578. eCollection 2020

Early morbidities following paediatric cardiac surgery: a mixed-methods study.

Brown KL, Pagel C, Ridout D, Wray J, Tsang VT, Anderson D, Banks V, Barron DJ, Cassidy J, Chigaru L, Davis P, Franklin R, Grieco L, Hoskote A, Hudson E, Jones A, Kakat S, Lakhani R, Lakhanpaul M, McLean A, Morris S, Rajagopal V, Rodrigues W, Sheehan K, Stoica S, Tibby S, Utley M, Witter T. Southampton (UK): NIHR Journals Library; 2020 Jul