Close
old-Functional Gene Annotation-changed 5 Dec 2018
Lead: Professor Ruth Lovering
Group Members: Dr Rachael Huntley, Dr Barbara Kramarz
We curate the scientific literature to provide;
Gene Ontology (GO) annotations to the GO Consortium
Protein interaction data to the IMEx Consortium
To date the annotation team at UCL has provided 12% of the GO annotations associated with human gene products, and contributed to the creation of almost 3000 new GO terms. We are currently funded by Alzheimer's Research UK and we have previously been funded by the British Heart Foundation and Parkinson's UK to annotate proteins and microRNAs. This gene product functional information enables researchers to rapidly evaluate and interpret data and generate hypotheses to guide future research into cardiovascular and neurological processes and disease.
In addition, as active members of the GO Consortium we participate in discussions about guidelines to ensure consistant approaches to annotation.
The Functional Gene Annotation team teaches a bioinformatics module for the UCL Genetics Institute's MSc in Genetics of Human Disease. We also run an annual workshop on GO and other bioinformatics resources. Contact us for further information.
What we do
Biocuration | Education and training |
| Biocuration is the translation of biological knowledge and its integration into databases thereby making the data easily accessible for visualisation and analysis. We curate the scientific literature to provide; Gene Ontology annotations to the GO Consortium Protein interaction data to the IMEx Consortium. This gene product functional information enables researchers to rapidly evaluate and interpret data and generate hypotheses to guide future research into cardiovascular and neurological processes. | The Functional Gene Annotation team teaches a bioinformatics module for the UCL Genetics Institute's MSc in Genetics of Human Disease. We also run an annual workshop on GO and other bioinformatics resources. Contact us for further information. |
Contribute
You can contribute by
- reviewing the annotation of your favourite gene and telling us what's missing or inaccurate (or tell us if we've done a good job!)
- suggesting papers for curation
Collaborators
The Functional Gene Annotation projects represent collaborations between;
- University College London (UCL)
- The Proteomic Services and UniProt development groups at European Bioinformatics Institute (EBI)
- Prof. Manuel Mayr's group at King's College London
- Prof. Nigel Hooper and Dr David Brough at the University of Manchester
- Gene Ontology Consortium (GOC)
The Functional Gene Annotation team is supported by Alzheimer's Research UK (grants ARUK-NAS2017A-1 and ARUK-NSG2018-003) and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.