UCL Institute of Cardiovascular Science


Paper in Nature

13 December 2018

About the Institute

A paper just out in Nature Communications describes the findings of a genome wide association analysis of carotid atherosclerosis measured by ultrasound imaging from up to 71,000 individuals from our own UCLEB consortium and the US-European CHARGE consortium. The paper identifies new loci, describes their relationship to stroke and coronary disease risk and illuminates the underpinning regulatory genes and pathways. The analysis also identifies druggable targets emerging from the findings.  The work was funded by BHF, UCL Hospitals NIHR BRC as well as other funders and one of the joint first authors is a graduate of the UCL BHF 4-year PhD programme. 

Nora Franceschini1, Claudia Giambartolomei et al; GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. https://www.nature.com/articles/s41467-018-07340-5