UCL Institute of Cardiovascular Science


Mohammed Shah

PhD Project Title: Investigating the role of extracellular DNA and innate immunity in cell death during ischemia-reperfusion injury in the myocardium.

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Supervisors: Professor Derek Yellon

Lay summary:

Myocardial Infarction (Heart Attack) remains the leading cause of death and cardiovascular morbidity worldwide. Coronary artery occlusion during a Heart Attack results in ischemia; which is a cessation of blood and oxygen to the heart resulting in the death of heart cells. Restoring the blood flow to the myocardium, called reperfusion, after a period of ischemia also results in an intense inflammatory response in the heart which also causes heart cell death, this is called ischemia-reperfusion injury. We aim to gain a better understanding of the inflammation during ischemia-reperfusion injury in the heart and are testing new anti-inflammatory agents in order to protect the heart during a Heart Attack.

My Background 

Prior to embarking on my PhD, I was a Specialist Registrar in Cardiology with extensive experience of working in the NHS as a Clinical Cardiologist throughout Manchester and South London. 
I hope to pursue a dual career as a Research Clinician in the NHS once iv finished my BHF Clinical Research Fellowship here at the Hatter Cardiovascular Institute.


MBChB BSc(hons) MRCP


BHF Clinical Research Fellowship 2018

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