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PhD Project Title: Midlife lung function with later-life brain volumes and white matter hyperintensity.
Supervisors: Prof Marcus Richards, Prof Jonathan Schott, Prof Rebecca Hardy, Dr Sarah James
Lay summary:
Decreased lung function has been associated with cognitive function and decline. Yet, the underlying causes remain poorly understood. Potential mechanisms proposed are, firstly, that chronic hypoxia, a potential consequence of low lung function, might lead to neurodegeneration. Second, reduced lung function might facilitate development of ischemic brain injury and develop white matter lesions. Third, impaired lung function has been associated with an increased risk of cardiovascular risk factors such as smoking and hypertension, which may mediate this relationship. Using Insight 46, a neuroscience sub-study embedded in the rich population-based age-homogenous birth cohort NSHD, we can now extend on previous research to assess the effects of lung function on global brain volume, white matter hyperintensity whilst adjusting for a wide range of cardiovascular confounders.
My Background
Background in fMRI studies in the frontal lobe epilepsy
Qualifications
2016-2017: MSc in Advanced Neuroimaging at UCL
2009-2013: Pre-clinical Medicine at University of Nottingham
Awards
2018 MRC 4-year PhD studentship, UCL
2017 Dean’s List, MSc Advanced Neuroimaging, UCL
Appointments
2018 Visiting Scholar, Department of Public health, SNU Medical school, Seoul, South Korea
2017 Imaging Analyst, IXICO
2016–2017 Health Care Assistant, Housing and care 21, Brentford & Camden
Contact details
han.seo.16@ucl.ac.uk