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Project: Targeting nucleotide metabolism in radiation and chemotherapy

Project: Targeting nucleotide metabolism in radiation and chemotherapy

  • Primary supervisor: Dr. Kasper Fugger
  • Secondary supervisor: Prof. Bart Vanhaesebroeck

This is a 4-year PhD studentship funded by CRUK RadNet City of London, which covers tuition fees at the UK rate and a stipend of £21,000 per year. The start date for this studentship is October/November 2022. 

Closing date: 20th September 2022 9.00am BST.  

Please note, you must be eligible for Home Fees status (or qualify for settled/presettled status) to be eligible to apply for this studentship.

Description

Nucleotides are essential for cell growth and viability and nucleotide metabolism is often deregulated in cancers which drives tumourigenesis and promote therapy resistance. We recently discovered that targeting nucleotide metabolism is a powerful new strategy to kill cancer cells and overcome therapy resistance (Fugger et al, Science 2021).


As a PhD student in our lab at UCL Cancer Institute, you will drive an ambitious and exciting project that investigates the molecular mechanisms that govern nucleotide metabolism in human cells with the goal of translating new discoveries into more effective radiation and chemotherapies. You will be trained in using state-of-the-art technologies (eg. genome-wide CRISPR screens, metabolomics, as well as cell and molecular biology methods) that are available at the world-class facilities at the Cancer Institute as well as through the RadNet City of London’s network (Francis Crick Institute, King’s College and Queen Mary University). Through our ongoing collaboration with biotech and pharma industry partners, you will also have the opportunity to gain insight into the drug discovery process.

More detailed information about the research project is available on request by contacting Dr. Kasper Fugger (
k.fugger@ucl.ac.uk).

Application Procedure

For more information and to apply, please download the following documents:

Shortlisting and notification will likely take place W/C 26th September. Queries about the application procedure or recruitment process should be directed to: ci.scholarships@ucl.ac.uk