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Head and Neck Cancer Biology - Clinical Outcomes and Surgery

Bench-to-Bedside Head and Neck Research Programme


Group Leader: Matt Lechner

Our research is focused on the role of SSTR2 in head and neck cancers, in particular sinonasal tumours and nasopharyngeal cancers, virally-induced head and neck cancer, surgical outcomes and global health challenges in the field of head and neck cancer.


Research 

1. Translational SSTR2 programme – Prognosis, imaging and therapy  

Our programme has identified and further explores the impact of SSTR2 as a marker for prognosis, imaging and therapy and is our flagship project. 

Publications
  1. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy. M. Lechner, et al.; Nature Communications. 2020; 12(1):117. doi: 10.1038/s41467-020-20308-8.

  2. Ultra-fast scalable estimation of single-cell differentiation potency from scRNA-Seq data; A. Teschendorff, A.K. Maity, X. Hu, C. Weiyan, M. Lechner; Bioinformatics. 2020, btaa987. doi: 10.1093/bioinformatics/btaa987

  3. Novel Biomarkers in Sinonasal Cancers: From Bench to Bedside. M. Lechner, J. Liu, V.J. Lund; Current Oncology Reports. 2020; 22(10):106.
  4. H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours. I. Lyskjaer, D. Lindsay, R. Tirabosco, C.D. Steele,  P. Lombard, A.C. Strobl, A.M. Rocha, C. Davies, H. Ye, E. Bekers, J. Ingruber, M. Lechner, F. Amary, N. Pillay, A.M. Flanagan. J Pathol. 2020;10.1002/path.5507. doi:10.1002/path.5507
  5. Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation? L. Masterson, J. Howard, J. Gonzalez-Cruz, C. Jackson, C.  Barnett, L Overton, H. Liu, R. Ladwa, F. Simpson, M. McGrath, B. Wallwork, T.M. Jones, C. Ottensmeier, M.L.K. Chua, C. Perry, R. Khanna, B. Panizza, S. Porceddu & M. Lechner; International Journal of Cancer. 2020;146(8):2305-2314. 
  6. Targeting mTOR in Head and Neck Cancer. L. Masterson, M. Lechner, T.M. Jones; Clinical Cancer Research. 2019;25(21):6554. 
  7. DNA methylation-based reclassification of olfactory neuroblastoma. D. Capper, N.W. Engel, D. Stichel, M. Lechner, S. Glöss, S. Schmid, C. Koelsche, D. Schrimpf, J. Niesen, A.K. Wefers, D.T.W. Jones, M. Sill, O. Weigert, K.L. Ligon, A. Olar, A. Koch, M. Forster, S. Moran, O.M. Tirado, M. Sáinz-Japeado, J. Mora, M. Esteller, J. Alonso, X.G. Del Muro, W. Paulus, J. Felsberg, G. Reifenberger, M. Glatzel, S. Frank, C.M. Monoranu, V.J. Lund, A. von Deimling, S. Pfister, R. Buslei, J. Ribbat-Idel, S. Perner, V. Gudziol, M. Meinhardt, U. Schüller. Acta Neuropathol. 2018. doi: 10.1007/s00401-018-1854-7. 
  8. DNA methylation-based classification of central nervous system tumours. D. Capper, D.T.W. Jones, M. Sill, V. Hovestadt, D. Schrimpf, D. Sturm, C. Koelsche, F. Sahm, L. Chavez, D.E. Reuss, A. Kratz, A.K. Wefers, K. Huang, K.W. Pajtler, L. Schweizer, D. Stichel, A. Olar, N.W. Engel, K. Lindenberg, P.N. Harter, A.K. Braczynski, K.H. Plate, H. Dohmen, B.K. Garvalov, R. Coras, A. Hölsken, E. Hewer, M. Bewerunge-Hudler, M. Schick, R. Fischer, R. Beschorner, J. Schittenhelm, O. Staszewski, K. Wani, P. Varlet, M. Pages, P. Temming, D. Lohmann, F. Selt, H. Witt, T. Milde, O. Witt, E. Aronica, F. Giangaspero, E. Rushing, W. Scheurlen, C.  Geisenberger, F.J. Rodriguez, A. Becker, M. Preusser, C. Haberler, R. Bjerkvig, J. Cryan, M. Farrell, M. Deckert, J. Hench, S. Frank, J. Serrano, K. Kannan, A. Tsirigos, W. Brück, S. Hofer, S. Brehmer, M. Seiz-Rosenhagen, D. Hänggi, V. Hans, S. Rozsnoki, J.R. Hansford, P. Kohlhof, B.W. Kristensen, M. Lechner, B. Lopes, C. Mawrin, R. Ketter, A. Kulozik, Z. Khatib, F. Heppner, A. Koch, A. Jouvet, C. Keohane, H. Mühleisen, W. Mueller, U. Pohl, M. Prinz, A. Benner, M. Zapatka, N.G. Gottardo, P.H. Driever, C.M. Kramm, H.L. Müller, S. Rutkowski, K. von Hoff, M.C. Frühwald, A. Gnekow, G. Fleischhack, S. Tippelt, G. Calaminus, C.M. Monoranu, A. Perry, C. Jones, T.S. Jacques, B. Radlwimmer, M. Gessi, T. Pietsch, J. Schramm, G. Schackert, M. Westphal, G. Reifenberger, P. Wesseling, M. Weller, V.P. Collins, I. Blümcke, M. Bendszus, J. Debus, A. Huang, N. Jabado, P.A. Northcott, W. Paulus, A. Gajjar, G.W. Robinson, M.D. Taylor, Z. Jaunmuktane, M. Ryzhova, M. Platten, A. Unterberg, W. Wick, M.A. Karajannis, M. Mittelbronn, T. Acker, C. Hartmann, K. Aldape, U. Schüller, R. Buslei, P. Lichter, M. Kool, C. Herold-Mende, D.W. Ellison, M. Hasselblatt, M. Snuderl, S. Brandner, A. Korshunov, A. von Deimling, Pfister SM; Nature. 2018; 555(7697):469-474.
More information

Management options for recurrent and metastatic disease are often limited in head and neck cancers. We have recently completed a study assessing the role of the somatostatin receptor 2 (SSTR2) in nasopharyngeal cancers and we are also working on the largest dataset of olfactory neuroblastoma in the world. With the promising efficacy of SSTR2 as a biomarker and therapeutic target in these head and neck cancers, we aim to better understand its role in other head and neck cancers and determine whether such information can be clinically exploited and linked to molecular data.  

Project Lead: Jacklyn Liu 
(Awarded UCL Graduate Research Scholarship/Overseas Research Scholarship)

Jacklyn Liu
SSTR2

 

 

2. HPV-associated Oropharyngeal Cancer – Awareness, epidemiology, molecular analysis, precursor lesions and early detection test 

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HPV-associated oropharyngeal squamous cell cancer (OPSCC) has one of the most rapidly rising incidences of any cancer in high income countries, having overtaken cervical cancer in the UK (M. Lechner, et al. Lancet Infect. Dis. 2019; 19: 131-132)

Publications
  1. Targeting key groups using a low-cost strategy to increase HPV awareness and vaccine uptake. O. Jones, C. Vassie, O. Emanuel, M. Lechner; Vaccine. 2020; in print. 
  2. Early detection of HPV-associated oropharyngeal cancer. M. Lechner et al.; Lancet. 2019; 393(10186):2123. 
  3. Gender-neutral HPV vaccination in the UK, rising male oropharyngeal cancer rates, and lack of HPV awareness. M. Lechner et al.; Lancet Infectious Diseases. 2019; 19(2):131-132. 
  4. A Cross-Sectional Survey of Awareness of Human Papillomavirus-associated Oropharyngeal Cancers among General Practitioners in the UK. M. Lechner, C. Vassie, C. Kavasogullari, O. Jones, J. Howard, L. Masterson, T. Fenton, W. Yarbrough, J. Waller, R. Gilson; BMJ Open. 2018; 8(7): e023339 
  5. Pan-cancer deconvolution of tumour composition using DNA methylation. A. Chakravarthy, A. Furness, K. Joshi, E. Ghorani, K. Ford, M.J. Ward, E.V. King, M. Lechner, T. Marafioti, S.A. Quezada, G.J. Thomas, A. Feber, T.R. Fenton. Nature Communications. 2018; 13;9(1): 3220. 
  6. Frequent HPV-independent p16/INK4A overexpression in head and neck cancer. M. Lechner, A.R. Chakravarthya, V. Walter, L. Masterson, A. Feber, A. Jay, P.M. Weinberger, R. McIndoe, C.T. Forde, K. Chester, N. Kalavrezos, P. O'Flynn, M. Forster, T.M. Jones, F. Vaz, N. Hayes, T.R. Fenton; Oral Oncology. 2018; 83: 32-37 
  7. Until eradication, awareness. O.S. Jones, C. Vassie, R. Gilson, M. Lechner; Lancet Infectious Diseases. 2017, 17(4): 368-369  
  8. Expanding the benefits of HPV vaccination to boys and men. L. Masterson, J. O'Mahony, M. Lechner; Lancet. 2017, 388(10063):2992  
  9. Human papillomavirus drives tumor development throughout the head and neck: Improved prognosis is associated with an immune response largely restricted to the oropharynx. A. Chakravarthy, S. Henderson, S.M. Thirdborough, C.H. Ottensmeier, X. Su, M. Lechner, A. Feber, G.J. Thomas, T. Fenton; Journal of Clinical Oncology. 2016, 34(34):4132-4141 
  10. The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer - Understanding the Basis of a Rapidly Evolving Disease. M. Lechner et T. Fenton; Advances in Genetics; 2016, 93: 1-56. 
  11. CD8+ T cell response to human papillomavirus 16 E7 is able to predict survival outcome in oropharyngeal cancer. L. Masterson, M. Lechner, S. Loewenbein, H. Mohammed, C. Davies-Husband, T. Fenton, H. Sudhoff, P. Jani, P. Goon, J. Sterling; European Journal of Cancer. 2016, 67:141-151. 
  12. Health policy: HPV vaccination in boys - will the UK join the fight? L. Masterson and M. Lechner; Nature Reviews of Clinical Oncology. 2016, 13(12):721-722  
  13. Deregulation of SYCP2 predicts early stage HPV+ oropharyngeal carcinoma – a prospective whole transcriptome analysis. L. Masterson, F. Sorgeloos, D. Winder, M. Lechner, A. Marker, S. Malhotra, H. Sudhoff, P. Jani, P. Goon, J. Sterling; Cancer Science; 2015, 106(11):1568-75. 
  14. Exploring the implications of HPV infection for head and neck cancer; N. Field & M. Lechner; Sexually Transmitted Infections; 2015, 91(4):229-30. 
  15. Epigenetics markers of metastasis and HPV-induced tumorigenesis in penile cancer; A. Feber, M. Arya, P. De Winter, M. Saqip, R. Nigam, P. Malone, W.S. Tan, S. Rodney, M. Lechner, A. Freeman, C. Jameson, A. Muneer, S. Beck, J.D. Kelly; Clinical Cancer Research, 2015, 21(5):1196-206 
  16. Using high-density DNA methylation arrays to profile copy number alterations; A. Feber, P. Guilhamon, M. Lechner, T. Fenton, G.A. Wilson, C. Thirlwell, A.M. Flanagan, A.E. Teschendorff, J.D. Kelly, S. Beck; Genome Biology. 2014, 15(2): R30 
  17. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing; G.M. Frampton, A. Fichtenholt, G.A. Otto, K. Wang, S.R. Downing, J. He, M. Schnall-Levin, J. White, E.M. Sanford, P. An, J. Sun, F. Juhn, K. Brennan, K. Iwanik, A. Maillet, J. Buell, E. White, M. Zhao, S. Balasubramanian, S. Terzic, T. Richards, V. Banning, L. Garcia, K. Mahoney, Z. Zwirko, A. Donahue, H. Beltran, J.M. Mosquera, M.A. Rubin, S. Dogan, C.V. Hedvat, M.F. Berger, L. Pusztai, M. Lechner, C. Boshoff, M. Jarosz, C. Vietz, A. Parker, V.A. Miller, J.S.  Ross, J. Curran, M.T. Cronin, P.J. Stephens, D. Lipson, R. Yelensky; Nature Biotechnology. 2013, 10.1038/nbt.2696. 
  18. Integrated virus-host methylome analysis in head and neck squamous cell carcinoma; G.A. Wilson & M. Lechner, A. Koeferle, H. Caren, L.M. Butcher, A. Feber, T. Fenton, A. Jay, C. Boshoff, S. Beck; Epigenetics. 2013, 18:8(9). 
  19. Targeted Next-generation Sequencing of Head and Neck Squamous Cell Carcinoma identifies novel genetic alterations in HPV+ and HPV- tumours. M. Lechner, G. Frampton, T. Fenton, A. Feber, G. Palmer, A. Jay, N. Pillay, M. Forster, M.T. Cronin, D. Lipson, V.A. Miller, T.A. Brennan, S. Henderson, F. Vaz, P. O'Flynn, N. Kalavrezos, R. Yelensky, S. Beck, P.J. Stephens, C. Boshoff; Genome Medicine. 2013, 5(5): 49. 
  20. Identification and Functional Validation of HPV-mediated Hypermethylation in Head and Neck Squamous Cell Carcinoma. M. Lechner, T. Fenton, J. West, G. Wilson, A. Feber, S. Henderson, C. Thirlwell, H.K. Dibra, A. Jay, L. Butcher, A.R. Chakravarthy, F. Gratrix, N. Patel, F. Vaz, P. O'Flynn, N. Kalavrezos, A.E. Teschendorff, C. Boshoff, S. Beck; Genome Medicine. 2013, 5(2): 15. 
  21. One-stop Triple-Imaging: The way forward in Head and Neck Cancer management? P. Randhawa, J. Jie, M. Lechner, J. Rimmer, T. Beale, S. Morley, F. Vaz; Bulletin of The Royal College of Surgeons of England. 2013, 95(5): 1-4. 
  22. A Beta-Mixture Quantile Normalisation method for correcting probe design bias in Illumina Infinium 450k DNA methylation data. A.E. Teschendorff, F. Marabita, M. Lechner, T. Bartlett, J. Tegner, D. Gomez-Cabrero and S. Beck; Bioinformatics. 2013, 29(2): 189-96.  
  23. Comments on: Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed paraffin-embedded paired tumor and normal tissue. C. Thirlwell, A. Feber, M. Lechner, A.E. Teschendorff, S. Beck; BMC Res Notes. 2012, 13(5): 631. 
  24. Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip. C. Thirlwell, M. Eymard, A. Feber, A.E. Teschendorff, K. Pearce, M. Lechner, M. Widschwendter, S. Beck; Methods. 2010, 52(3):248-54.     
  25. Cancer Epigenome. M. Lechner, C. Boshoff, S. Beck; Advances in Genetics. 2010, Vol. 70, Chapter 9; pages 247-276.  
More information

The increasing rates of HPV-positive OPSC will have a tremendous healthcare cost, with estimated overall cost for treatment in the UK amounting to £2 billion over the next twenty years (in men only). Taking into account broader societal costs, we estimate that HPV-positive OPSCC will cost the UK more than £18 billion over the next twenty years (M. Lechner et al.; Lancet. 2019; 393: 2123)

According to the AJCC 8th edition staging guidelines, HPV-positive OPSCC is distinct from its HPV-negative counterpart, which is largely caused by tobacco use and predominantly affects older men. In contrast, HPV-positive OPSCC is caused by oncogenic HPV infection and tends to impact younger men, with a distinct and unique molecular profile. Importantly, HPV positivity confers an improved prognosis. However, positive clinical outcome is hindered by a lack of effective prevention and early detection measures, which is exacerbated by low awareness of the link between HPV infection and OPSCC, particularly in men. Of 1,200 respondents in a UK-wide, population-based survey (649 [54.1%] female), only 444 (37.0%; 95% CI 34.3–39.7) had ever heard of HPV. Of these, 309 (69.6%; 65.2–73.7) knew that HPV could be transmitted during sex, 172 (38.7%; 34.3–43.3) recognised HPV as a risk factor for oropharyngeal squamous cell cancer, and 283 (63.7%; 59.2–68.1) knew that a preventive vaccine existed. Women were almost twice as likely to be aware of HPV as were men (290 [44.7%] vs 154 [27.9%]; p<0.001) (Ml. Lechner et al. Lancet Infectious Diseases. 2019; 19(2):131-132). This is important as OPSCC is often detected at a late stage, which directly impacts clinical outcome and survival. Improving public awareness of the cancer risk as well as educating individuals on symptoms would not only reduce the incidence but also aid in earlier detection. Importantly, Primary care physicians (GPs) are at the nexus of the general public and our healthcare systems and have the ability to promote public health initiatives. In survey across primary care physicians, we found that while 74% of primary care physicians recognised HPV as a risk factor for OPSCC, less than half were aware that being male was a risk factor for HPV-associated OPSCC (M. Lechner, et al. BMJ Open. 2018; 8: e023339).  

In an effort to improve awareness, we are developing a questionnaire, which would function as an educational tool as well as enable risk stratification of participants for a future screening program for persistent HPV infection and oropharyngeal cancer. We are investigating the role of various lifestyle factors, such as tobacco, marijuana and alcohol use as well as education, age and sex as potential stratification markers in addition to better understanding knowledge of OPSCC and HPV.  

HPV-positive OPSCC is treated in much the same way as HPV-negative disease and centres on surgery and chemoradiotherapy. There are ongoing efforts to de-escalate treatment due to the high incidence of treatment-related adverse events and reduced post-treatment quality of life. However, there is much need for an improved understanding of the molecular profile of these tumours as well as the identification of clinically important risk factors in order to properly stratify patients and allocate treatment accordingly. This will further add to the identification of therapeutic targets and the development of precision medicine, including the paramount task of identifying biomarkers for early detection. We previously identified and validated patterns of hypermethylation HPV-associated head and neck cancer using Infinium 450k BeadArray and whole-genome methylated DNA immunoprecipitation sequencing (MeDIP-seq) technologies. We are currently investigating methylation variable positions in HPV-OPSCC in a spectrum of HPV-associated oropharyngeal tissues (from healthy individuals, to those with persistent infection and ultimately OPSCC) in order to identify markers of malignant transformation for early detection. We are also investigating the role of CEA and B7-H3 in OPSCC. We have found that both are overexpressed in OPSCC and ongoing investigations are focused on determining their diagnostic and prognostic utility, as well as their potential use as therapeutic targets. Ultimately, we aim to develop a diagnostic test which can be easily achieved on clinical samples, such as saliva, in order to support broad screening programs.

Project Lead: Oscar Emanuel
(PhD application submitted)

   

HPV and Oropharyngeal Cancer
Oscar Emanuel

 

 

3. Clinical applications and outcomes in skull base surgery and Head and Neck Cancer

Sinonasal cancers arise from the nasal cavities and paranasal sinuses and comprise of a wide spectrum of histologically and clinically distinct disease entities, with a total incidence between 0.5-1.0 cases per 100,000 men and women per year. This represents a significant challenge with regards to diagnosis and treatment options, particularly for advanced stage disease.

Overall, clinical outcomes have remained unchanged over recent years and there is a clear need for new therapeutic options. This UCL led programme aims to collect the largest clinical and surgical outcome datasets of the most common sinonasal cancers with a large group of multi-institutional collaborators and partners from all across the world.

Publications

1.  Precision medicine in rare tumors and the need for multicenter trials and international collaboratives: Sinonasal cancer as paradigm. P. Bossi, M. Hermsen, M. Lechner, A. Franchi. Oral Oncology. 2020;104737; doi:10.1016/j.oraloncology.2020.104737

2. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy. M. Lechner, et al.; Nature Communications. 2020; 12(1):117. doi: 10.1038/s41467-020-20308-8.

3. Ultra-fast scalable estimation of single-cell differentiation potency from scRNA-Seq data; A. Teschendorff, A.K. Maity, X. Hu, C. Weiyan, M. Lechner; Bioinformatics. 2020, btaa987. doi: 10.1093/bioinformatics/btaa987

4. Novel Biomarkers in Sinonasal Cancers: From Bench to Bedside. M. Lechner, J. Liu, V.J. Lund; Current Oncology Reports. 2020; 22(10):106.

5. H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours. I. Lyskjaer, D. Lindsay, R. Tirabosco, C.D. Steele,  P. Lombard, A.C. Strobl, A.M. Rocha, C. Davies, H. Ye, E. Bekers, J. Ingruber, M. Lechner, F. Amary, N. Pillay, A.M. Flanagan. J Pathol. 2020;10.1002/path.5507. doi:10.1002/path.5507

6. Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation? L. Masterson, J. Howard, J. Gonzalez-Cruz, C. Jackson, C.  Barnett, L Overton, H. Liu, R. Ladwa, F. Simpson, M. McGrath, B. Wallwork, T.M. Jones, C. Ottensmeier, M.L.K. Chua, C. Perry, R. Khanna, B. Panizza, S. Porceddu & M. Lechner; International Journal of Cancer. 2020;146(8):2305-2314. 

7. Targeting mTOR in Head and Neck Cancer. L. Masterson, M. Lechner, T.M. Jones; Clinical Cancer Research. 2019;25(21):6554. 

8. DNA methylation-based reclassification of olfactory neuroblastoma. D. Capper, N.W. Engel, D. Stichel, M. Lechner, S. Glöss, S. Schmid, C. Koelsche, D. Schrimpf, J. Niesen, A.K. Wefers, D.T.W. Jones, M. Sill, O. Weigert, K.L. Ligon, A. Olar, A. Koch, M. Forster, S. Moran, O.M. Tirado, M. Sáinz-Japeado, J. Mora, M. Esteller, J. Alonso, X.G. Del Muro, W. Paulus, J. Felsberg, G. Reifenberger, M. Glatzel, S. Frank, C.M. Monoranu, V.J. Lund, A. von Deimling, S. Pfister, R. Buslei, J. Ribbat-Idel, S. Perner, V. Gudziol, M. Meinhardt, U. Schüller. Acta Neuropathol. 2018. doi: 10.1007/s00401-018-1854-7. 

9. DNA methylation-based classification of central nervous system tumours. D. Capper, D.T.W. Jones, M. Sill, V. Hovestadt, D. Schrimpf, D. Sturm, C. Koelsche, F. Sahm, L. Chavez, D.E. Reuss, A. Kratz, A.K. Wefers, K. Huang, K.W. Pajtler, L. Schweizer, D. Stichel, A. Olar, N.W. Engel, K. Lindenberg, P.N. Harter, A.K. Braczynski, K.H. Plate, H. Dohmen, B.K. Garvalov, R. Coras, A. Hölsken, E. Hewer, M. Bewerunge-Hudler, M. Schick, R. Fischer, R. Beschorner, J. Schittenhelm, O. Staszewski, K. Wani, P. Varlet, M. Pages, P. Temming, D. Lohmann, F. Selt, H. Witt, T. Milde, O. Witt, E. Aronica, F. Giangaspero, E. Rushing, W. Scheurlen, C.  Geisenberger, F.J. Rodriguez, A. Becker, M. Preusser, C. Haberler, R. Bjerkvig, J. Cryan, M. Farrell, M. Deckert, J. Hench, S. Frank, J. Serrano, K. Kannan, A. Tsirigos, W. Brück, S. Hofer, S. Brehmer, M. Seiz-Rosenhagen, D. Hänggi, V. Hans, S. Rozsnoki, J.R. Hansford, P. Kohlhof, B.W. Kristensen, M. Lechner, B. Lopes, C. Mawrin, R. Ketter, A. Kulozik, Z. Khatib, F. Heppner, A. Koch, A. Jouvet, C. Keohane, H. Mühleisen, W. Mueller, U. Pohl, M. Prinz, A. Benner, M. Zapatka, N.G. Gottardo, P.H. Driever, C.M. Kramm, H.L. Müller, S. Rutkowski, K. von Hoff, M.C. Frühwald, A. Gnekow, G. Fleischhack, S. Tippelt, G. Calaminus, C.M. Monoranu, A. Perry, C. Jones, T.S. Jacques, B. Radlwimmer, M. Gessi, T. Pietsch, J. Schramm, G. Schackert, M. Westphal, G. Reifenberger, P. Wesseling, M. Weller, V.P. Collins, I. Blümcke, M. Bendszus, J. Debus, A. Huang, N. Jabado, P.A. Northcott, W. Paulus, A. Gajjar, G.W. Robinson, M.D. Taylor, Z. Jaunmuktane, M. Ryzhova, M. Platten, A. Unterberg, W. Wick, M.A. Karajannis, M. Mittelbronn, T. Acker, C. Hartmann, K. Aldape, U. Schüller, R. Buslei, P. Lichter, M. Kool, C. Herold-Mende, D.W. Ellison, M. Hasselblatt, M. Snuderl, S. Brandner, A. Korshunov, A. von Deimling, Pfister SM; Nature. 2018; 555(7697):469-474.

More information

Skull Based Surgery and Head and Neck Cancer

 

 

4. Head and Neck Cancer and the 100,000 Genomes Project

Genomics England Clinical Interpretation Partnership (GeCIP).

The 100,000 Genomes Project has demonstrated that genomics can play a pivotal role in improving diagnosis and treatment for patients with head and neck cancer. Around 400 patients with head and neck cancer have been recruited to the 100,000 Genomes Project. Already we have seen changes in practice in pathology laboratories as a result of this project.

Preliminary analysis of the genomes shows that more accurate diagnoses can be provided, and patients with germline alterations can be identified more readily. Moreover, this project has resulted in a more collaborative and comprehensive research strategy for many of the rare head and neck cancers.

More information

Whole Genome Sequencing results returned by tumour type from Genomics England (n=16,370).

More information about Genomics England Clinical Interpretation Partnership (GeCIP) can be found here.

Head and Neck Cancer and 100,000 Genomes

 

5. Betel nut-induced Oral Cancer – Awareness, early detection and targeted therapies 

Mouth cancer is a debilitating but largely preventable disease with a high incidence in countries, such as India, Taiwan and Papua New Guinea. In the UK, roughly 8000 cases arise each year. It is primarily caused by lifestyle behaviours, specifically tobacco, alcohol and betel nut use. We have IRB approval to collect global prevalence and awareness data and also work on an early detection test on betel nut induced oral cancer. Moreover, this project will result in a more collaborative research strategy.

Publications

1. Betel nut chewing in high-income countries – lack of awareness and regulation. M. Lechner, C. Breeze, F. Vaz, V.J. Lund, B. Kotecha. Lancet Onc. 2019; 20: 181-183.  

More information

Betel nut is an addictive substance chewed by one-tenth of the global population and is a known cause of mouth cancer. In a study conducted in Pune, India, we found that 40% of individuals chew betel nut and those who chew were significantly less likely to be aware of its cancer risk, compared to non-chewers. In the UK, we have found that over half of respondents chew betel more than once per year and are also significantly less aware of its cancer risk. Additionally, more than one quarter of GPs were unaware of betel nut being a risk factor for throat cancer. It is evident that this is an issue on both the national and global scale.  

One of the main limiting factors to poor survival in mouth cancer is late detection of disease. There are no validated biomarkers and targeted therapies are lacking. We have sought to advance this field by conducting targeted whole-genome deep sequencing of tumour specimens, which we collected in Pune, India, in partnership with Deenanath Mangeshkar Hospital and Foundation Medicine. This analysis enabled us to determine a panel of genes which are frequently mutated in our tumour cohort and may serve as a potential diagnostic or prognostic biomarker.  

In addition, we are working toward improving awareness of betel nut-associated mouth cancer through the dissemination of a large, international cross-sectional survey to assess the prevalence of betel nut use while simultaneously providing education and support. The innovative data collection tool named BICRAA (bicraa.org) enables us to collect data on betel nut use through secure questionnaires, while also enabling users to determine their risk of mouth cancer and obtain the necessary assistance. We aim to extend the permutation within the app, which would link high risk users with the relevant medical help, including the appropriate mouth screening. We are currently validating our tool and aim to implement it in India in the near future, in partnership with Deenanath Mangeshkar Hospital in Pune, India.

Project Leads:
Shruti Patel

Shruti Patel
Jacklyn Liu 
 (Awarded UCL Graduate Research Scholarship / Overseas Research Scholarship)

Jacklyn Liu

 

 

 

 

 

Betel Nut
 

 

 

6. Sars-CoV-2 (COVID-19) - Symptom prevalence, diagnostic screening and clinical trials

Anosmia, the loss or change in the sense of smell, was first confirmed as an official symptom of Covid-19 on 21 April 2020 by the Centers for Disease Control and Prevention (CDC) and has been widely reported as a key symptom of Covid-19 infection. We are running our own multi-centre trial to provide olfactory training and are also working very closely with other groups to further facilitate in-depth research into Covid-19 and loss of smell and taste. 

Publications
  1. Course of symptoms for loss of sense of smell and taste over time in one thousand forty-one healthcare workers during the Covid-19 pandemic. M. Lechner, et al.; Clinical Otolaryngology. 2020, in print.
  2. Anosmia as a presenting symptom of SARS-CoV-2 infection in healthcare workers – A systematic review of the literature, case series, and recommendations for clinical assessment and management. M. Lechner, et al. Rhinology. 2020; doi: 10.4193/Rhin20.189.
  3. Loss of smell and taste: a new marker of COVID-19? Tracking reduced sense of smell during the coronavirus pandemic using search trends. G. Cherry, J. Rocke, M. Chu, J. Liu, M. Lechner, V.J. Lund, B.N. Kumar. Expert Rev Anti Infect Ther. 2020;1-6. doi:10.1080/14787210.2020.1792289
  4. Olfactory Loss of Function as a Possible Symptom of COVID-19. M. Lechner, Z.M. Patel, C. Philpott, V.J. Lund; JAMA Otolaryngology - Head and Neck Surgery. 2020,10.1001/jamaoto.2020.1589. doi:10.1001/jamaoto.2020.1589
  5. Anosmia and hyposmia in health-care workers with undiagnosed SARS-CoV-2 infection. M.Lechner et al.; The Lancet Microbe. 2020, 1(4): e150
  6. Association of subjective olfactory dysfunction and 12‐item odor identification testing in ambulatory COVID‐19 patients. D.P. Prajapati, B. Shahrvini, B. Macdonald, Kavya L. Crawford, M. Lechner, A.S. DeConde, C.H. Yan; International Forum of Allergy & Rhinology. 2020; DOI: 10.1002/alr.22688
More information

COVANOS Trial UK

COVANOS Trial UK
Chief Investigators: Matt Lechner, Valerie J Lund
Project Coordinator: Jacklyn Liu 

 


Our COVID-19 Collaborators: 

 

SAFER-PLUS

 

Main collaborator: Eleni Nastouli 
Liaison lead: Jacklyn Liu

The COVID19 Consortium  

The COVID19 Consortium

 
 
 
Main collaborators: James Moon, Tom Treibel 
Liaison lead: David Gillespie 

 


Global Consortium for Chemosensory Research (GCCR)

GCCR
Liaison lead: David Gillespie

UK COVID-19 and Anosmia Cohort Study

 
Main collaborators: Rachel Batterham, Janine Makaronidis 

 

Other Publications 

1. Squamous cell cancer of the temporal bone: a review of the literature. M. Lechner et al. European Archives of Otorhinolaryngology. 2020; 10.1007/s00405-020-06281-4. doi:10.1007/s00405-020-06281-4

2. Intratympanic steroid use for idiopathic sudden sensorineural hearing loss: current otolaryngology practice in Germany and Austria. L. Sutton, V. Schartinger, C. Url, J. Schmutzhard, D. Lechner, C. Kavasogullari, J.S. Sandhu, A. Shaida, R. Laszig, J. Loehler, S. Plontke, H. Riechelmann, M. Lechner; 2018; Eur Arch Otorhinolaryngol; 2018; 275(5): 1103-1010

3. Otorhinolaryngology and Diving-Part 1: Otorhinolaryngological Hazards Related to Compressed Gas Scuba Diving. M. Lechner, L. Sutton, J.M. Fishman, D.M. Kaylie, R.E. Moon, L. Masterson, C. Klingmann, M.A. Birchall, V.S. Lund, J.S. Rubin; JAMA Otolaryngol Head Neck Surg. 2018 Mar 1;144(3):252-258

4. Otorhinolaryngology and Diving-Part 2: Otorhinolaryngological Fitness for Compressed Gas Scuba Diving. M. Lechner, L. Sutton, J.M. Fishman, D.M. Kaylie, R.E. Moon, L. Masterson, C. Klingmann, M.A. Birchall, V.J. Lund, J.S. Rubin; JAMA Otolaryngol Head Neck Surg. 2018 Mar 1;144(3):259-263

5. Advancing the grading for drug-induced sleep endoscopy-a useful modification of the Croft-Pringle Grading System. B. Kotecha, M. LechnerSleep and Breathing. 2018; 22(1):193-194.

6. Attitudes to local anaesthesia in radiofrequency thermotherapy (RFTT) sleep surgery: Our experience in a single centre with 42 adult patients. E. Warner, Z.W. Liu, M. Lechner, B. Kotecha; Clinical Otolaryngology; 2018; doi: 10.1111/coa.13155

7. Barriers to improving tracheostomy care in low- and middle-income countries: our experience of a 23 patient closed loop audit cycle. L. Sutton, M. Mozaffari, A. Mintarti, A. Narula, S.R. Indrasari & M. Lechner; Clinical Otolaryngology; 2018; doi: 10.1111/coa.13151

8. Letter to the Editor Regarding Comparison of 2 and 4 Intratympanic Steroid Injections in the Treatment of Idiopathic Sudden Sensorineural Hearing Loss by Suzuki et al. L. Sutton, J.T. McElveen, G. Brookes, A. Shaida,M. Lechner; Ann Otol Rhinol Laryngol. 2018; 127(7): 481-482

9. Snoring and breathing pauses during sleep: interview survey of a United Kingdom population sample reveals a significant increase in the rates of sleep apnoea and obesity over the last 20 years - data from the UK sleep survey. M. Lechner et al.; Sleep Medicine. 2018; 54: 250-256

10. Intratympanic steroid use for sudden sensorineural hearing loss: Current otolaryngology practice; M. Lechner, L. Sutton, M. Ferguson, Y. Abbas, J. Sandhu, A. Shaida; Ann Otol Rhinol Laryngol. 2019;128(6):490-502.