UCL Cancer Institute Seminar Series

The cancer genome contains within it an archaeological record of its past. Dr Van Loo's research lab developed approaches to disentangle the subclonal architecture and the life history of cancers based on massively parallel sequencing data, collectively termed 'molecular archaeology of cancer'. In an on-going pan-cancer analysis of 2,600 whole-genome sequenced tumours, the team are gaining insights into the extent of heterogeneity in different tumour types and the order and timing of acquisition of genetic aberration.

Hosted by: Dr Javier Herrero

The seminar will be followed by a sandwich buffet lunch

Selected Publications

Gundem, G; Van Loo, P; Kremeyer, B; Alexandrov, LB; Tubio, JMC; Papaemmanuil, E; Brewer, DS; Kallio, HML; Högnäs, G; Annala, M; Kivinummi, K; Goody, V; Latimer, C; O'Meara, S; Dawson, KJ; Isaacs, W; Emmert-Buck, MR; Nykter, M; Foster, C; Kote-Jarai, Z; Easton, D; Whitaker, HC; ICGC Prostate UK Group; Neal, DE; Cooper, CS; Eeles, RA; Visakorpi, T; Campbell, PJ; McDermott, U; Wedge, DC and Bova, GS (2015). The evolutionary history of lethal metastatic prostate cancer. Nature 520, 353-357.

Nik-Zainal, S; Van Loo, P; Wedge, DC; Alexandrov, LB; Greenman, CD; Lau, KW; Raine, K; Jones, D; Marshall, J; Ramakrishna, M; Shlien, A; Cooke, SL; Hinton, J; Menzies, A; Stebbings, LA; Leroy, C; Jia, M; Rance, R; Mudie, LJ; Gamble, SJ; Stephens, PJ; McLaren, S; Tarpey, PS; Papaemmanuil, E; Davies, HR; Varela, I; McBride, DJ; Bignell, GR; Leung, K; Butler, AP; Teague, JW; Martin, S; Jönsson, G; Mariani, O; Boyault, S; Miron, P; Fatima, A; Langerød, A; Aparicio, SAJR; Tutt, A; Sieuwerts, AM; Borg, Å; Thomas, G; Salomon, AV; Richardson, AL; Børresen-Dale, A-L; Futreal, PA; Stratton, MR; Campbell, PJ and Breast Cancer Working Group of the International Cancer Genome Consortium (2012). The life history of 21 breast cancers. Cell 149, 994-1007.

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Van Loo, P; Nordgard, SH; Lingjærde, OC; Russnes, HG; Rye, IH; Sun, W; Weigman, VJ; Marynen, P; Zetterberg, A; Naume, B; Perou, CM; Børresen-Dale, A-L and Kristensen, VN (2010). Allele-specific copy number analysis of tumors. Proceedings of the National Academy of Sciences of the United States of America 107, 16910-16915.

For further information, go to https://www.crick.ac.uk/peter-van-loo

Location

Courtyard Café
UCL Cancer Institute
Paul O'Gorman Building
London, WC1E 6DD

Contact: Veronica Dominguez v.dominguez@ucl.ac.uk

This seminar has been part-sponsored by Merck, the Biomedical Research Centre and Cancer Research UK

Image: Dr Peter Van Loo receives the Cancer Research UK Future Leaders in Cancer Research Prize, NCRI conference 2016