UCL Cancer Institute Seminar Series

The 100,000 Genomes project is using whole genome sequencing to bring diagnoses to patients with rare inherited disorders, identify drivers to cancer and response to therapy and drivers to antimicrobial resistance in pathogens. This will transform the capability and capacity of the NHS to apply genomic medicine for patient benefit. This programme will be carried out in England requiring the NHS and third party providers to create new leading edge infrastructure and operational plans for day to day NHS Practice. With NHS England we have created 13 NHS Genomic Medicine Centres across England to enable generation of clinical data and sample flows from NHS patients with broad consent for whole genome sequencing into our Genomics England Biorepository at the NIHR Biosample centre. We are creating one of the largest X Ten Next Generation Sequencing Centres in the World at Hinxton with our partner Illumina. The value of this programme will be the alignment of the highest fidelity and most comprehensive whole genome DNA sequence produced from patients to date with high fidelity clinical data stored in pseudonymised format within a multi-petabyte data infrastructure. This will allow ongoing refreshment from primary, secondary and tertiary NHS care to offer a picture of life-course health and disease progression for participants. To drive up diagnoses for patients we have created the Genomics England Clinical Interpretation Partnership where 2100 clinicians and scientists will work on pseudonymised builds to enhance value for patients.  Alongside this significant enhancement of NHS capability for utilisation of next generation sequencing in clinical care we will train with 530 person years of Masters Training the next generation of clinicians and scientists to ensure that NHS capacity to harness Genomic Medicine is the most advanced in the world.

Hosted by Professor Stephan Beck

The seminar will be followed by a sandwich buffet lunch

Selected publications

Siva N. UK gears up to decode 100 000 genomes from NHS patients. The Lancet .2015

Caulfield M, Ainsworth C.Q&A: Mark Caulfield. National genomics. Nature 2015

Location

UCL Cancer Institute
Courtyard Café
Paul O'Gorman Building 
72 Huntley Street
London, WC1E 6DD

Further information

• Genomics England - The 100000 Genomes Project
• Professor Mark Caulfield profile (Board of Genomics England)

This seminar has been sponsored in part by Taconic Bioscience, the Biomedical Research Centre and Cancer Research UK