UCL Cancer Institute Seminar Series

Professor Gerald de Haan, University Medical Centre Groningen, presents: (Two) Cell-intrinsic pathways that regulate hematopoietic stem cell self-renewal, Thursday 20 October 12pm

Hematopoietic stem cells carefully balance selfrenewal and differentiation, in order to sustain peripheral blood cell homeostasis during the lifetime of an organism. We have recently uncovered two pathways that control selfrenewal decisions, both in mouse and man. The first involved microRNA125, which is uniquely able to induce long-term repopulating stem cell potential in non-stem cells. The second involves the epigenetic Polycomb group protein Cxb7, which is essential for selfrenewal in both normal and leukemic stem cells.

Professor Gerald de Haan academic profile

Hosted by: Professor Tariq Enver

The seminar will be followed by a sandwich buffet lunch

Selected publications:

Wojtowicz EE, Lechman ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman-Grant A, Dobson SM, Krivdova G, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers-Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G. Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors. Cell Stem Cell. 2016 Sep 1;19(3):383-96. doi: 10.1016/j.stem.2016.06.008. Epub 2016 Jul 14. PMID: 27424784

Verovskaya E, Broekhuis MJ, Zwart E, Weersing E, Ritsema M, Bosman LJ, van Poele T, de Haan G, Bystrykh LV. Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines. J Exp Med. 2014 Mar 10;211(3):487-97. doi: 10.1084/jem.20131804. Epub 2014 Feb 24. PMID: 24567446

Klauke K, Radulović V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.  Nat Cell Biol. 2013 Apr;15(4):353-62. doi: 10.1038/ncb2701. Epub 2013 Mar 17. PMID: 23502315

Location

Courtyard Café
UCL Cancer Institute
Paul O'Gorman Building
London, WC1E 6DD

Contact: Veronica Dominguez v.dominguez@ucl.ac.uk

This seminar has been sponsored in part by Merck, the Biomedical Research Centre and Cancer Research UK