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UCL Cancer Institute Seminar Series

28 January 2016, 12:00 pm–2:00 pm

A microscopic view of cell division

Professor Buzz Baum, LCMB, presents: The mechanics of normal and cancer cell divisions, Thursday 28th January, 12pm

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Organiser

UCL Cancer Institute

Location

UCL Cancer Institute

In the lab, Professor Baum and his group are interested in the generation of biological form. Since the shape and internal organisation of each cell is determined by a combination of physics, biochemistry and information processing, the team use a wide range of techniques to address the problem (including molecular biology, genetics, high-content RNA interference (RNAi) screening, live cell imaging, microfabrication, biophysical techniques and computational modeling). The wider aims of the group's research are to better understand the evolution of eukaryotic cell shape, to determine how cells regulate their form, and to determine how these processes contribute to normal tissue development and homeostasis and, when they go awry, to the evolution of metastatic cancer.

Hosted by Professor Bart Vanhaesebroeck

The seminar will be followed by a sandwich buffet lunch 

References

  1. Rodrigues, N. T. L., Lekomtsev, S., Jananji, S., Kriston-Vizi, J., Hickson, G. R. X., & Baum, B. (2015). Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation. Nature, 524 (7566), 489-492. doi:10.1038/nature14496
  2. Lancaster, O. M., Le Berre, M., Dimitracopoulos, A., Bonazzi, D., Zlotek-Zlotkiewicz, E., Picone, R., . . . Baum, B. (2013). Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formation. Dev Cell, 25 (3), 270-283. doi:10.1016/j.devcel.2013.03.014
  3. Matthews, H. K., Delabre, U., Rohn, J. L., Kunda, P., Guck, J., & Baum, B. (2012). Changes in ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Developmental Cell, 23 (2), 371-383. doi:10.1016/j.devcel.2012.06.003

 


Location

UCL Cancer Institute
Courtyard Café
Paul O'Gorman Building 
72 Huntley Street
London, WC1E 6DD