UCL Cancer Institute Seminar Series

Professor Amanda Fisher, Imperial College London, presents: Linking epigenetics and signaling in the early mammalian embryo. Thursday 10th December, 12pm

Professor Fisher produced the first functional copies of HIV, providing researchers with access to enough biologically active material to study the function of the virus’s genes. She later became interested in epigenetics and nuclear reprogramming, particularly in white blood cells known as lymphocytes and embryonic stem cells. Her current research focuses on  how cells acquire specialized functions and how this identity is transmitted as cells divide. Prof Fisher’s lab uses reprogramming strategies to test the resilience of cellular memory mechanisms and to explore the requirements for lineage conversion. In this seminar, Amanda will discuss two new studies that have revealed how epigenetic interactions help to shape the development of the mammalian embryo.

References

1. Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development. Landeira D, Bagci H, Malinowski AR, Brown KE, Soza-Ried J, Feytout A, Webster Z, Ndjetehe E, Cantone I, Asenjo HG, Brockdorff N, Carroll T, Merkenschlager M, Fisher AG. Cell Rep. 2015 Jul 28;12(4):573-86.

2. Getting rid of DNA methylation. Piccolo FM, Fisher AG.Trends Cell Biol. 2014 Feb;24(2):136-43.

3. DNA synthesis is required for reprogramming mediated by stem cell fusion. Tsubouchi T, Soza-Ried J, Brown K, Piccolo FM, Cantone I, Landeira D, Bagci H, Hochegger H, Merkenschlager M, Fisher AG.Cell. 2013 Feb 14;152(4):873-83

Hosted by Ivana Bjedov

The seminar will be followed by a sandwich buffet lunch 

Location

UCL Cancer Institute
Courtyard Café
Paul O'Gorman Building 
72 Huntley Street
London, WC1E 6DD